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  Exponential Epigenetic Affects - The rise of Man Made Diseases ...


D. S. McGerk | March/2017


Topic: Exponential Epigenetic Affects -

In our previous 2 articles Intergenerational Transmission of Epigenetics, and Carbohydrate Sensitivity - Intolerance we begin to see a pattern that has developed over the last 200 years. We're now starting to realize that this carbohydrate sensitivity has led to Intolerance and this has manifested as Insulin Resistance or Metabolic Syndrome. This condition is proving to be the leading driving factor of 80% of current human diseases and death. Our Health and Longevity are at stake. In addition our Health, Longevity, and chances at becoming a "Centenarian" are in Jeopardy

Liz Parrish - CEO of BioViva USA Inc (1) is committed to building gene therapies to eradicate disease and extend healthy life, Transcending the Aging Paradigm | Liz Parrish, CEO of BioViva USA, May/2015 . (1a) Liz and Dr. Bill Andrews (2) are involved in Aging as a Disease and Dr. Andrews talks about his research with telomerase ... Dr. Bill Andrews presents Telomere Research | Feb/2017 (2a)

Historical View | Causes of Death - 1900 vs. 2010

, dying of "Old Age" was considered unusual. Fully 1 of 3 babies died within the first year. We have eliminated most of the infectious diseases of children and the middle years, leaving us with the real possibility of dying from old age or perhaps living longer in a healthy fashion.

As you can see, deaths from infectious diseases have gone way down compared to 1900, while the proportion of people dying from cancer has tripled.

means increasing maximum lifespan and healthspan. Live to 100 or Beyond is the target goal with 1 day in a moribund state.

has allowed doctors (Note: 1) to more effectively treat many diseases that might have caused people to die in the early 20th century; hence, the discrepancy in total deaths tallied. But recognizing cancer, in particular, has become a lot more common during the past century and it isn't as easily treatable, especially since we are fueling these diseases with our SAD - lifestyle.

the first Regenerative Medicine and they still work. They accounts for 50% of our elimination of infectious diseases. Then of couse there is the invention of Sanitation which comes with a better understanding of our symbiotic world.

are the only Preventative Medicine that we have and these work very well. Our researchers and scientists are trying to discover new vaccines. Many people do not like this idea, but they have a proven history of working and have virtually eliminated infectious diseases, (Ref: 3) (Note: 2) and diagram below. Death from infectious diseases, - in 1665 91% ⇒ 3% in 2010.

changes influence Behavioral Medicine and intervention.

    Remove bad habits - Smoking

  1. This is accounting for a 10% improvement in all-cause mortality.

    But, Governmental and Societal Ignorance has allowed -

  1. The shift to high consumption of processed and fast foods as a major portion of the diet.
  2. The switch to high Omega-6 Poly-unsaturated diets.
  3. Exposure to over 100,000 industrial toxins never before seen in the history of mankind released into the environment by the hundreds of thousands of tons.
  4. Mass use of known carcinogens such as chlorine and fluoride in the public water supply.

Humans and Disease | We have made some bad choices

Cellular Degeneration underlies biological aging and is the Master Disease. Can we cure this? Cancers, cardiovascular degeneration, neurodegeneration of brain and our nervous systems are symptoms of this aging disease. But, we can take action independent of our medical system to catch up.

containing large amounts of sugar, refined flour, and polyunsaturated omega-6 oils are greatly depleted of a wide range of vitamins and minerals. Dr. Ames' Triage Theory predicts that even a marginal deficiency of some of these micronutrients may play a major role in the pathogenesis of CHD. In addition, some components of processed food, such as trans fatty acids, heated vegetable oils and sucrose, may have a direct toxic effect on the cardiovascular system.

have created their own demise by creating Man-made ailments that are driving cardiovascular failure, blood metabolism failure, immune system malfunction, neurodegeneration, cancer - a metabolic disease, and insulin resistant diseases such as Type 2 diabetes and Type 3 diabetes (Alzheimer's - Diabetes of the Brain). Functionally all of these can be traced to Inflammation and Insulin Resistance and Modern Malnutrition.

the human body can tolerate some damage from metabolic processes, but not too much. It is up the the User of the Body to make sure all the repair materials are on hand to make repairs. Nutritional deficiency will inhibit this repair process - hence disease and death.

How we can finally win the fight against aging, Aubrey de Grey | Jan/2017 (12) is Aubrey's position against Aging and discusses his point of view which is ... Personally I don't like it. Our own point of view ... What is the Future of Nutrition, and is it Important? | contributor February/2017 is an analysis of Ray Kurzweil's and Aubrey de Grey's views.

 

 

are still an experiment and it is an incomplete Failing Experiment. For example, using Statins to control Fats is nonsense as they also affects all the Fat soluble Vitamins. In addition, Cholesterol is Vital to cellular construction and our metabolism of Vitamin D.

Starving Pathogens - Our body's Nutritional Immunity Response, did you know that our body even has such a mechanism? Ref: ... Nutritional Immunity System | contributor january/2017. In the 1930's Warburg (wikipedia) showed that Cancer preferred Fermentation as its primary fuel source, which is the metabolizing of Sugars and hence are susceptible to Starvation on a Fat-Adapted Diet. (Note: 3)

People with Insulin Resistance (13) are normally diagnosed with pre-diabetes and often have slightly higher levels of inflammation throughout their bodies. In insulin resistance, muscle, fat, and liver cells do not respond properly to insulin and thus cannot easily absorb glucose from the bloodstream. As a result, the body needs higher levels of insulin to help glucose enter cells. The more insulin levels rise, the more insulin resistant cells become. Over time, this vicious cycle can lead to persistently elevated blood glucose levels, or type 2 diabetes.

People who are on a High Carbohydrate Diet will have many different dietary triggered diseases. Humans have hybridized foods for the last 10,000 years in favor of Palatability and Sweetness ("Less Bitter") e.g. our benzodiazepine and opioid systems (Brain). (14,15,a,b,c) It is reported that almost 50% of Americans (JAMA-2016) are "Pre-Diabetic" which by definition contradicts eating carbohydrates. The low fat diet has failed, it is time for a LCHF eating lifestyle.

We cannot solve problems by using the same kind of thinking, we used when we created them." ... Albert Einstein

People with a Poor Nutritional Lifestyle without Exercise manifest many metabolic symptoms. Key knowledge: We are turning off the immune system with a poor diet. The body favors short-term survival over long-term health. This trade-off accelerates aging-associated diseases, such as cancer, cardiovascular disease, immune dysfunction, and cognitive decline. High carbohydrate diets shut down the body’s own antioxidant defense genes. This is accelerated by high omega-6 polyunsaturated fats.

High carbohydrate diets - that are also high in omega-6 fats, shut down and confuse the body’s own antioxidant defense genes’ anti-oxidant pathways which are far more powerful than any supplement you can take. Scarce micronutrient - are reallocated to nutritional pathways essential for short-term survival. Pathways needed for long term health, (including those that protect DNA), lose out leading to the diseases of aging. (30,31,32,33)

Humans are on this Path? | We Love our Opioids

(15a) attach to receptors in the brain. Normally these opioids are the endogenous variety that are created naturally in the body. Once attached, they send signals to the brain of the "opioid effect" which blocks pain, slows breathing, and has a general calming and anti-depressing effect. The body cannot produce enough natural opioids to stop severe or chronic pain nor can it produce enough to cause an overdose. (Note: 4)

Our brains are wired to ensure that we will repeat life-sustaining activities by associating those activities with pleasure or reward. Whenever this reward circuit is activated, the brain notes that something important is happening that needs to be remembered, and teaches us to do it again and again, without thinking about it. Because drugs of abuse stimulate the same circuit, we learn to abuse drugs in the same way.

, it is a growth hormone and regulates fat storage and growth. Ref: 2 contributions - Carbohydrates and Longevity | contributor October/2016, and this one ... Carbohydrate Intolerance - What does this mean? | contributor February/2016.

 

 

Ok - Now What?

Aging - Cellular Damage, today gene therapy is considered an Experimental Science, but tomorrow it will be the solution. Targeting DNA damage or a cancer will be normal.

can be considered a Gene Therapy [Brandhorst S, Choi L, et al. cell Metabolism, 2015] A FMD - Fasting Mimicking Diet, reverses the effects of aging as discussed by Dr. Longo ... Fasting: Awakening the Rejuvenation from Within | Valter Longo | TEDxEchoPark - December.2016 his approach to FMD ⇒ 1000 cal for 5 day once a month ⇒ 3 month ⇒ stem cells activated and all risks dropped. CPR, Pre-Diabetes, stem cell % 0.4 to 0.8. this process turns on stems cells and you get a coordinated response from all organs. Ref: Fasting - How it helps our Metabolic Repair System | contributor March/2017.

passes on Diet and Life Style Choices to the next generation by DNA markers through Epigenetics. Good Genes Aren’t Enough new research indicates that in order to keep from passing on traits that might be harmful to our kids, it’s important to keep our DNA healthy. Epigenetic information is passed down not just to the next generation but to future generations. (3,4,5,6) Understanding Intergenerational transmission of genetic changes and traits is Epigenetics.

means increasing maximum lifespan and healthspan by using our sciences with diet, healthy living, and exercise as the foundation, with the goal of becoming Centenarians. Live to 100 or Beyond is the target goal with 1 day in a moribund state. This point of view is held by Dr. Vince Giuliano - AgingSciences. (11)

are professionally designed to maximize reward, because reward is precisely what keeps you coming back for more - "Sucker". We are on an Addictive Path and it may be Too Late to stop the Exponential Epigenetic Affects.

Hyper-Palatables Foods = Sugar = Cocaine = Dopamine

are our Achilles Heel and we don't even realize it yet. We still think there is nothing wrong with refined carbohydrates. The sugar industry and the other parts of the chemical industry have ignored the mounting evidence and continue to produce their own biased data. Dr. Lustig as been at the forefront of the Sugar War which we refer to as the modern Weapon of Mass Destruction - WMD as this addiction will invariably kill more people than any other thing that Man has made. Ref: Dr. Lustig on sugar ... Dr. Lustig - Sugar: The Bitter Truth July/2009 and the Addictive Path as described by Dr. Pamela Peeke. Her book The Hunger Fix, states that science shows that you may actually be addicted to certain “hyperpalatables” which are typically sugary/fatty/salty refined and processed food combinations. (Irony 1) (7,8,9)

Beginnings of Refined Carbohydrate Era, the following slide demonstrates that within the last 300 years cultural changes occurred. These were done in favor of mass production and economics. Cultural choices were made without considerations and nutrition was nver considered. The drive for Less Bitter and more Palatable foods started over 200 years ago and continues to accelerate. ref: Premise: Eat Real Foods.

LCHF and ketone energy vs. carbohydrates the non-essential macronutrient

Conclusion: the human animal was never intended to metabolize glucose/glycogen in large quantities, instead we metabolize and store fats. Insulin is a very weak hormone and just barely can regulate 100mg/dl in our blood. Fat-adaptation is the normal, preferred metabolic state of the human body. Sugar-dependency is an abnormal metabolic state that inevitably leads to insulin resistance and chronic disease. (17,17a)

We suffer from to much carbohydrates, hence, Carbohydrate Intolerance and Inflammation | contributor february/2017. Being able to mobilize and oxidize stored fat during exercise can reduce an athlete's reliance on glycogen. This is the classic "train low, race high" phenomenon, and it can improve performance, save the glycogen for the truly intense segments of a session, and burn more body fat. Ref: ... Hypothesis - Flight or Fight Response | contributor october/2016

Discover how well you are aging

 


Irony Notes:

  1. When the hero Achilles was an infant, his sea-nymph mother dipped him into the river Styx to make him immortal. But since she held him by one heel, this spot did not touch the water and so remained mortal and vulnerable, and it was here that Achilles was eventually mortally wounded. Today, the tendon that stretches up the calf from the heel is called the Achilles tendon. But the term Achilles' heel isn't used in medicine; instead, it's only used with the general meaning "weak point"—for instance, to refer to a section of a country's borders that aren't militarily protected, or to a Jeopardy contestant's ignorance in the Sports category. Our week point is

    Hyper-Palatables Foods = Sugar = Cocaine = Dopamine

    Addictive Path as described by Dr. Pamela Peeke. Her book The Hunger Fix. Science now shows that you may actually be addicted to certain “hyperpalatables” which are typically sugary/fatty/salty refined and processed food combinations. Whole foods are rarely to blame.

Notes:

  1. It takes up to 5 years for doctors to acquire information we can get today, and most of it is fed to them through Big-Pharma. In this day and age The Individual must take charge of their own health. Dr. Rhonda Patrick gives a quick tutorial on tools to make genetic and nutritional decisions with. How to Personalize Your Nutrition Based On Genetics | Dr. Rhonda Patrick, March/2015 (B)
  2. Longevity and the triage theory of nutrients The discovery of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk originally coined the term “vitamines” from the Latin vitals (vitally important) and amines (organic derivatives of ammonia). The major period of discovery began in the early nineteenth century and ended at the mid-twentieth century. (20) The puzzle of each vitamin was solved through the work and contributions of epidemiologists, physicians, physiologists, and chemists. We all know the discover of the cure to Scurvy, and Vitamin C, also, beriber (B1), (21) rickets, pellagra (B3), and xerophthalmia as specific vitamin deficiencies. Many Nobel Prizes came out of the research on vitamins, there discovery, isolation, synthesis and structure. (23)
  3. that cancer is not a genetic, but a metabolic disease, we can change our fundamental strategy and address our diet. Diet alone will not solve the cancer riddle. It will likely prevent it. Hippocrates, on Balance and Harmony, and Ames - Triage Theory on Reallocation - Scarce Resources; also, the Chinese Yin and Yang Theory.
    When you look at all the science behind cancer, it brings to mind, body, spirit, lifestyle, the immune system, diet and detoxification ...
    Glucose Metabolism is one of the primary considerations within our mitochrondria, a theory initially brought forth by Dr. Otto Warburg - (Video) in the 1920s. (wikipedia) In 1931, Warburg won the Nobel Prize in Physiology for Medicine for his discovery that cancer cells have a fundamentally different energy metabolism compared to healthy cells. The nuclear genetic defects typically thought to be responsible for cancer actually occur further downstream. Mitochondrial damage happens first, which then triggers nuclear genetic mutations that may lead to cancer. (24,25,26)
  4. Opioids attach to receptors in the brain. Normally these opioids are the endogenous variety that are created naturally in the body. ... Dopamine is a neurotransmitter present in regions of the brain that regulate movement, emotion, cognition, motivation, and feelings of pleasure.

 


[ + ] Sources and References:

  1. Ref 1 CDC.gov, NVSS - National Vital Statistics Report, Jan 2012, Deaths: Preliminary Data for 2010, by Sherry L. Murphy, B.S.; Jiaquan Xu, M.D.; and Kenneth D. Kochanek, M.A., Division of Vital Statistics
  2. Ref 2 CDC.gov, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NCHS Data Brief, No. 88, Mar 2012, 75 Years of Mortality in the United States, 1935–2010, Donna L. Hoyert, Ph.D.
  3. Ref 3 ONS.gov.uk, Office for National Statistics Compendium: Mortality, 2014-based national population projections reference volume
  4. A youTube Dr. Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance
  5. B youTube, How to Personalize Your Nutrition Based On Genetics, Dr. Rhonda Patrick, March/2015
  6. 1 Liz Parrish - CEO of BioViva USA Inc
  7. 1a Liz Parrish on youTube, Transcending the Aging Paradigm | Liz Parrish, CEO of BioViva USA, May/2015
  8. 2 Dr. Andrews - Curing Aging, CEO SIERRA SCIENCES is a biotech company.
  9. 2a Dr. Andrews on youTube, Dr. Bill Andrews presents Telomere Research | Feb/2017
  10. 3 NCBI PubMed - Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12222-7. doi: 10.1073/pnas.1316740111. Epub 2014 Jul 28. Intergenerational transmission of emotional trauma through amygdala-dependent mother-to-infant transfer of specific fear. Debiec J, Sullivan RM.
  11. 4 Cell - CellPress Nucleus, Volume 161, Issue 6, p1453–1467, 4 June 2015 A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development, Walfred W.C et al.
  12. 5 University of Cambridge - Research, Reprogramming of DNA observed in human germ cells for first time
  13. 6 Scitable by Nature Education, The Role of Methylation in Gene Expression, By: Theresa Phillips, Ph.D. (Write Science Right) © 2008 Nature Education
  14. 7 Gary Null at the Progressive Radio Network: War on Health - Gary Null's documentary exposing the FDA.
  15. 8 Dr. Rath, Health Foundation, The History of the Pharma-Cartel
  16. 9 Dr. Mercola - Take Control of your Health, Pulling Back the Curtain on the Organized Crime Ring That Is the Pharmaceutical Drug Carte
  17. 10 Dr. Axe - Food is Mecicine, 9 Charts That Show Why America is Fat, Sick & Tired.
  18. 10a American Society for Clinical Nutrition, 2007, Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Richard J Johnson, et al.
  19. 11 AgingSciences - Anti-Aging Firewalls, Presentation videos - The Science and Technology of Longevity, 2016 by Vince Giuliano
  20. 12 Aubrey de Grey, youTube 2017, How we can finally win the fight against aging, Aubrey de Grey | Jan/2017
  21. 13 NIH - Diabetes, Digestive, and Kidney Diseases, Prediabetes & Insulin Resistance
  22. 14 NCBI PubMed Nutr Rev. 2003 May;61(5 Pt 2):S5-9. Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  23. 15 OnlineLibrary - Wiley, .pdf Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  24. 15a New Yori Times, Richard A. Friedman MD, Professor Cornell Medicine – Psychiatrist, Jun/2017. What Cookies and Meth Have in Common?
  25. 15b NIH, National Institue of Diabetes, Digestive and Kidney Diseases, Prediabetes and Insulin Resistance, What is insulin?
  26. 15c Diagnosis Diet, Dr. Georgia Ede, How to Diagnose, Prevent and Treat Insulin Resistance.
  27. 17 Peak Fitness, mercola.com, What Does It Mean to Be Fat Adapted? By Mark Sisson
  28. 17a Primal Blueprint, Mark Sisson WHAT IS THE PRIMAL BLUEPRINT? by Mark Sisson.
  29. 20 PubMed, The discovery of the vitamins. Semba RD.
  30. 21 Nobel Prize.org, Christiaan Eijkman, Beriberi and Vitamin B1
  31. 22 Nobel Prize.org, The Nobel Prize and the Discovery of Vitamins, by Kenneth J. Carpenter
  32. 24 Travis Christofferson, "Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure." The Metabolic Theory of Cancer and the Key to Cancer Prevention and Recovery
  33. 25 Mercola.com - How Nutrition Influences Cancer, Is it possible that chromosomal damage is simply a marker for cancer and not the actual cause of the disease?
  34. 26 youTube Dr. Gary Fettke - A Nutritional model of Inflammation & Modern Disease.
  35. 30 youTube by Dr. Ames - 2015, Bruce Ames: Vitamin & Mineral Inadequacy Accelerates Aging-associated Disease
  36. 31 NCBI PMC, Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47): 17589–17594. PMCID: PMC1693790, Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage, Bruce N. Ames.
  37. 32 PNAS, .pdf file, Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage, Dr. Ames, Nutrition and Metabolism Center, Children's Hospital of Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609.
  38. 33 youTube, by Dr Patrick, Micronutrients for the Prevention of Age-Related Diseases and Brain Dysfunction | Dr. Rhonda Patrick | June/2016

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