Nutritional Ketosis - Optimize Your Mitochondrial Metabolism

D. S. McGerk | January/2017

Topic: Nutritional Ketosis - Optimize your Mitochondrial Metabolism.

We're now starting to realize that mitochondrial dysfunction is at the core of virtually all diseases, and support for nutritional ketosis is growing by leaps and bounds. 2016 was a breakthrough year for this kind of information.

for Ketogenic Therapies was founded in 1994 to provide information about diet therapies for people with epilepsy, other neurological disorders and select cancers. They use all available approaches to therapies and with ketosis therapy they are achieving 10-25% seisure free with their patients.

One of the reasons it works so well is because it drives your inflammation - aka insulin resistance - aka metabolic syndrome down to very low levels. When inflammation disappears, your body can heal.


Optimize your Mitochondrial Metabolism

Nutritional Ketosis is when our metabolism runs off of energy that comes from our reserved fat instead of glucose. We are just beginning to understand the biological intricacies of aging. A growing body of research is challenging the belief that aging is beyond your control, prompting scientific research ... In a report published in the August 2013 issue of Cell Reports, (6) scientists discovered that the "mTOR gene" is a significant regulator of the aging process ..." (5).

Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Cancer: A Metabolic Disease With Metabolic Solutions | Dr. Thomas Seyfried | march/2015. (10,10a) .

Burning glucose, an inherently "dirty" fuel as it generates far more reactive oxygen species (ROS) than fat and ketones. But in order to burn ketones, the cell must be healthy and normal. Cancer cells cannot burn fat, and this is the heart of successful cancer treatment, and why ketogenic diets appear to be so effective. They essentially starve the cancer, while nourishing healthy cells.

Discover how well you are aging


Ketosis is not Ketoacidosis

Ketosis ≠ Ketoacidosis - Ketones are Fuel

Ketoacidosis (aka Diabetic Ketosis - DKA) is a life-threatening condition in which your body doesn’t make enough insulin. This can cause you to have dangerously high levels of ketones and blood sugar. This combination makes your blood too acidic, which can change the normal functioning of internal organs like your liver and kidneys. If you don’t get prompt treatment for it, you could go into a coma or die.

This was first discovered in the Urine of Type I diabetics. A high level of Ketones were measured in the urine indicating that the body was not processing carbohydrates. Poor diabetes management is a leading trigger for DKA. But today, we know that Type II diabetes can be over come or controlled with a LCHF diet. Avoiding MetS - Metabolic Syndrome is a key issure with lifestyle. Ref: Addictions ... the Obesogenic Diet.

longevity and carbohydrates on shorter lifespan Ketosis is a normal state of metabolism, whereby, our bodies move in and out of Fat Burning mode. If you have ketosis, you have a higher than usual level of ketones in your blood or urine. Ketones are a chemical your body produces when it burns stored fat.

Ketones are a more efficient energy fuel for our metabolism. A low carbohydrate diet can trigger ketosis. That is because a low-carb diet will cause you to have less glucose in your blood, which will, in turn, cause you to produce less insulin. Your body will begin to burn fat for energy instead of relying on sugars. Ref: Carbohydrates and Longevity | contributor october/2016.

The Pyramid indicates that in both cases of either Ketosis or Ketoacidosis the body's first line of defense is Low Carbohydrates. Low carbs promote the body's optimum metabolism and an example of this was published in 1996 by S. G. Hasselbalch,, in the American Journal of Physiology ...
A ketogenic state results in a substantial (39%) increase in cerebral blood flow, and appears to reduce cognitive dysfunction associated with systemic hypoglycemia in normal humans. (30)
Also on this site ... Carbohydrate Intake - Prevents Fat Burning

Best selling author Nora Gedgaudas - Primal Body Primal Mind goes beyond the Paleo Diet for total health and a longer life, (i.e. becoming a Centenarian). She has good a video back by hard science, and has her own popular podcasts are on iTunes ... or her site ... Primal mind: Nutrition and mental health - Improving the way you feel and function, cultivating an ageless mind, by Nora Gedgaudas. . (32,33)

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  1. Longevity and the triage theory of nutrients The discovery of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk originally coined the term “vitamines” from the Latin vitals (vitally important) and amines (organic derivatives of ammonia). The major period of discovery began in the early nineteenth century and ended at the mid-twentieth century. (21) The puzzle of each vitamin was solved through the work and contributions of epidemiologists, physicians, physiologists, and chemists. We all know the discover of the cure to Scurvy, and Vitamin C, also, beriber (B1), (21a) rickets, pellagra (B3), and xerophthalmia as specific vitamin deficiencies. Many Nobel Prizes came out of the research on vitamins, there discovery, isolation, synthesis and structure. (21b)
  2. However, in the Paleo world, this source was probably intermittent (unless living near Tidal Pools). In our diet they are disappearing - "Where did the Omega 3's Go" contributor. The modern diet is referred to as "The Obesogenic Diet" a term created by Dr. Rhonda Patrick. The Centenarian diet uses the Asian approach to these protein sources. Meat and seafood are not the primary entree, but used as an accoutrement or feasting. We eat too much protein and this is very hard on the kidneys. Medical data shows we only need about 1/3 what we eat today.
    The Soft Diet comes from cooking and humans get a net energy gain. Catching Fire: How Cooking Made Us Human | Dr. Richard Wrangham, february/13. (Video)
  3. The Cell is a perfect lean mean machine, and we replace all of our cells regularly. Our bodies are doing this every second, plus DNA repair, and immune responses. The cell has evolved to grow, reproduce, and repair itself. 2 billion years to achieve this, then they started organizing ... The Human - 2 Biological Organisms in One.
    Our favorite youTube presentations on the cell are: TED TALK: The secret, social lives of bacteria, Dr. Bonnie Bassler | april/09 (Video) (22) Chemical Conversations: How Bacteria Talk to Each Other , Dr. Bonnie Bassler | august/10 (23)




[ + ] Sources and References:

  1. org The Noakes Foundation, Our goal is to support the dietary revolution that will reverse the global epidemics of obesity and type 2 diabetes mellitus (DM).
  2. Rub youTube Nutrition Forum - Dr. Donald Layman, PhD, june/2013.
  3. RubADub Crain Medicine, Ancestral Knowledge for a Modern World, A Spoonful of Sugar Helps the Medicine Go Up! DAVID HASTINGS LLOYD, feb/2015
  4. RubADub-Dub youTube, Eric Westman, MD, MHS -- LCHF Treatment of Diabetes, jul/2015
  5. 5 The Aging of Mice and Men, By Dr. Mercola, Ketogenic Diet Improves Insulin Sensitivity and Numerous Aging Markers
  6. 6, Cell Report - Volume 4, Issue 5, p913-920, 12 September 2013, Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression, Slowing of Aging after Genetic Reduction of mTOR Expression,J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, Nisha Narayan, Marie M. Fergusson, Ilsa I. Rovira, Michele Allen, Danielle A. Springer, Cory U. Lago, Shuling Zhang, Wendy DuBois, Theresa Ward, Rafael deCabo, Oksana Gavrilova, Beverly Mock, Toren Finkel
  7. 10 Travis Christofferson, author of the phenomenal book, "Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure."
  8. 10a youTube, Cancer: A Metabolic Disease With Metabolic Solutions, Dr. Thomas Seyfried. mar/15
  9. 20, Courses, Cholesterol, Lipoproteins and the Liver.
  10. 20a University of Washington, Home Page.
  11. 21 The Washington Post, The U.S. government is poised to withdraw longstanding warnings about cholesterol, by Peter Whoriskey February 10, 2015
  12. 21a youTube, Vitamin K: New Evidence for Cancer, Heart Health, and Bone Health
  13. 21b RHR, Revolution Health Radio, Can Vitamin K2 Prevent Cardiovascular Disease, by Chris Kresser, L.Ac.
  14. 21c The Washington Post, Peter Whoriskey, Cholesterol in the Diet: The Long Slide from Public Menace to No "Appreciable" Effect, Peter Whoriskey.
  15. 22 wikipedia, Ancel Benjamin Keys (January 26, 1904 - November 20, 2004), an American scientist.
  16. 23 The Saccharine Disease aka, Refined-Carbohydrate Disease, The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, by Thomas L. Cleave.
  17. 30 NCBI PubMed, Am J Physiol. 1996 May;270(5 Pt 1):E746-51. Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB.
  18. 32 Ancestral Health Society - Primal Body Primal Mind, Primal mind: Nutrition and mental health - Improving the way you feel and function, cultivating an ageless mind, by Nora Gedgaudas.
  19. 33 Primal Body Primal Mind, Nora Gedgaudas, Primal Body Primal Mind.

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