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Intergenerational Transmission of Epigenetics - our own demise ...


D. S. McGerk | February/2017


Topic: Intergenerational Transmission of Epigenetics - Extinction of the Human Society

Have we created our own extinction level event?

In our previous article Carbohydrate Sensitivity - Intolerance, we begin to see a pattern that has developed over the last 200 years. We're now starting to realize that this carbohydrate sensitivity has led to Intolerance and this has manifested as Insulin Resistance or Metabolic Syndrome. This condition is proving to be the leading cause of 80% of current human diseases and death. Our Health and Longevity are at stake. In addition our Health, Longevity, and chances at becoming a "Centenarian" are in Jeopardy

have created their own demise by creating Man-made ailments that are driving cardiovascular failure, blood metabolism failure, immune system malfunction, neurodegeneration, cancer - a metabolic disease, and insulin resistant diseases such as Type 2 diabetes and Type 3 diabetes (Alzheimer's - Diabetes of the Brain). Functionally all of these can be traced to Inflammation and Insulin Resistance and Modern Malnutrition.

passes on Diet and Life Style Choices to the next generation by DNA markers. Good Genes Aren’t Enough new research indicates that in order to keep from passing on traits that might be harmful to our kids, it’s important to keep our DNA healthy. Epigenetic information is passed down not just to the next generation but to future generations. (1,2,3,4) Understanding Intergenerational transmission of genetic changes and traits is Epigenetics.

 

 

are professionally designed to maximize reward, because reward is precisely what keeps you coming back for more - "Sucker". We are on an Addictive Path and it may be Too Late to stop the Exponential Epigenetic Affects.

Hyper-Palatables Foods = Sugar = Cocaine = Dopamine

are our Achilles Heel and we don't even realize it yet. We still think there is nothing wrong with refined carbohydrates. The sugar industry and the other parts of the chemical industry have ignored the mounting evidence and continue to produce their own biased data. Dr. Lustig has been at the forefront of the Sugar War which we refer to as the modern Weapon of Mass Destruction - WMD as this addiction will invariably kill more people than any other thing that Man has made. Ref: Dr. Lustig on sugar ... Dr. Lustig - Sugar: The Bitter Truth July/2009 and the Addictive Path as described by Dr. Pamela Peeke. Her book The Hunger Fix, states that science shows that you may actually be addicted to certain “hyperpalatables” which are typically sugary/fatty/salty refined and processed food combinations. (Irony 1) (5,6,7)

Humans are on this Path? | We Love our Opioids

attach to receptors in the brain. Normally these opioids are the endogenous variety that are created naturally in the body. Once attached, they send signals to the brain of the "opioid effect" which blocks pain, slows breathing, and has a general calming and anti-depressing effect. The body cannot produce enough natural opioids to stop severe or chronic pain nor can it produce enough to cause an overdose. (Note: 1)

Our brains are wired to ensure that we will repeat life-sustaining activities by associating those activities with pleasure or reward. Whenever this reward circuit is activated, the brain notes that something important is happening that needs to be remembered, and teaches us to do it again and again, without thinking about it. Because drugs of abuse stimulate the same circuit, we learn to abuse drugs in the same way.

 

 

Genetic Corruption by Refined Carbohydrates

Hypothesis | Diet changes the Body's Epigenetics

Understanding Nutrigenonics and Epigenetics - meaning On top of Genetics, is critical to the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship. Dr. Rhonda Patrick - Nutrigenomics, Epigenetics, and Stress Tolerance | april/15 (A) Epigenetics is establishing the mechanisms of gene expression and diet, and how we pass diet markers onto the next generation. Diet-Gene Interactions, Epigenetics, the Vitamin D-Serotonin Link and DNA Damage | Dr. Rhonda Patrick, february/16 (12,13,14) (Note: 2)

Epigenetics is changing everything and this changes our understanding about the responsibility of this generation to the next - Example: What Grandma Ate, A new study looks at how epigenetic effects are passed down | Harvard Medical School, by Jeff Bright (15) shows that genes pass on a "Memory" of nutrition. Epigenetic effects are passed down from one generation to the next. Methylation patterns are major drivers of gene expression that change with aging and exercise profound effects on our health and longevity.

Historical View | Sugar Consumption vs. Epigenetic Effects

The data is indicating that there is a threshold, 10kg/22lb per year/person, and of above this the body does not seem to be responding well. A threshold where Refined Farming Products start to become dominant, triggers a metabolic response. Besides Obesity, there is a corresponding increase in diseases from Metabolic Syndrome and Inflammation. Ref: Nutrigenomics and Epigenetics | contributor July/2016.

, it is a growth hormone and regulates fat storage and growth. Ref: 2 contributions - Carbohydrates and Longevity | contributor October/2016, and this one ... Carbohydrate Intolerance - What does this mean? | contributor February/2016.

 

 

Ok - Now What?

Beginnings of Refined Carbohydrate Era, the following slide demonstrates that within the last 300 years cultural changes occurred. These were done in favor of mass production and economics. Cultural choices were made without considerations and nutrition was never considered. The drive for Less Bitter and more Palatable foods started over 200 years ago and continues to accelerate. ref: Premise: Eat Real Foods.

LCHF and ketone energy vs. carbohydrates the non-essential macronutrient

Conclusion: the human animal was never intended to metabolize glucose/glycogen in large quantities, instead we metabolize and store fats. Insulin is a very weak hormone and just barely can regulate 100mg/dl in our blood. Fat-adaptation is the normal, preferred metabolic state of the human body. Sugar-dependency is an abnormal metabolic state that inevitably leads to insulin resistance and chronic disease. (17,17a)

We suffer from to much carbohydrates, hence, Carbohydrate Intolerance and Inflammation | contributor february/2017. Being able to mobilize and oxidize stored fat during exercise can reduce an athlete's reliance on glycogen. This is the classic "train low, race high" phenomenon, and it can improve performance, save the glycogen for the truly intense segments of a session, and burn more body fat. Ref: ... Hypothesis - Flight or Fight Response | contributor october/2016

Track Your Nutrition & Health Data with cronometer.com

 


Irony Notes:

  1. When the hero Achilles was an infant, his sea-nymph mother dipped him into the river Styx to make him immortal. But since she held him by one heel, this spot did not touch the water and so remained mortal and vulnerable, and it was here that Achilles was eventually mortally wounded. Today, the tendon that stretches up the calf from the heel is called the Achilles tendon. But the term Achilles' heel isn't used in medicine; instead, it's only used with the general meaning "weak point"—for instance, to refer to a section of a country's borders that aren't militarily protected, or to a Jeopardy contestant's ignorance in the Sports category. Our week point is

    Hyper-Palatables Foods = Sugar = Cocaine = Dopamine

    Addictive Path as described by Dr. Pamela Peeke. Her book The Hunger Fix. Science now shows that you may actually be addicted to certain “hyperpalatables” which are typically sugary/fatty/salty refined and processed food combinations. Whole foods are rarely to blame.

Notes:

  1. Opioids attach to receptors in the brain. Normally these opioids are the endogenous variety that are created naturally in the body. ... Dopamine is a neurotransmitter present in regions of the brain that regulate movement, emotion, cognition, motivation, and feelings of pleasure.
  2. It takes up to 5 years for doctors to acquire information we can get today, and most of it is fed to them through Big-Pharma. In this day and age The Individual must take charge of their own health. Dr. Rhonda Patrick gives a quick tutorial on tools to make genetic and nutritional decisions with. How to Personalize Your Nutrition Based On Genetics | Dr. Rhonda Patrick, March/2015 (B)
  3. Longevity and the triage theory of nutrients The discovery of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk originally coined the term “vitamines” from the Latin vitals (vitally important) and amines (organic derivatives of ammonia). The major period of discovery began in the early nineteenth century and ended at the mid-twentieth century. (20) The puzzle of each vitamin was solved through the work and contributions of epidemiologists, physicians, physiologists, and chemists. We all know the discover of the cure to Scurvy, and Vitamin C, also, beriberi (B1), (21) rickets, pellagra (B3), and xerophthalmia as specific vitamin deficiencies. Many Nobel Prizes came out of the research on vitamins, there discovery, isolation, synthesis and structure. (23)

 


[ + ] Sources and References:

  1. A youTube Dr. Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance
  2. B youTube, How to Personalize Your Nutrition Based On Genetics, Dr. Rhonda Patrick, March/2015
  3. 1 NCBI PubMed - Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12222-7. doi: 10.1073/pnas.1316740111. Epub 2014 Jul 28. Intergenerational transmission of emotional trauma through amygdala-dependent mother-to-infant transfer of specific fear. Debiec J, Sullivan RM.
  4. 2 Cell - CellPress Nucleus, Volume 161, Issue 6, p1453–1467, 4 June 2015 A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development, Walfred W.C et al.
  5. 3 University of Cambridge - Research, eprogramming of DNA observed in human germ cells for first time
  6. 4 Scitable by Nature Education, The Role of Methylation in Gene Expression, By: Theresa Phillips, Ph.D. (Write Science Right) © 2008 Nature Education
  7. 5 Gary Null at the Progressive Radio Network: War on Health - Gary Null's documentary exposing the FDA.
  8. 6 Dr. Rath, Health Foundation, The History of the Pharma-Cartel
  9. 7 Dr. Mercola - Take Control of your Health, Pulling Back the Curtain on the Organized Crime Ring That Is the Pharmaceutical Drug Carte
  10. 8 youTube, Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance, Apr/15
  11. 10b Dr. Axe - Food is Mecicine, 9 Charts That Show Why America is Fat, Sick & Tired.
  12. 10c American Society for Clinical Nutrition, 2007, Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Richard J Johnson, et al.
  13. 12 youTube, Rhonda Patrick on Diet-Gene Interactions, Epigenetics, the Vitamin D-Serotonin Link and DNA Damage, Feb/16
  14. 13 DNA Repair (Effects of micronutrients on DNA repair, Eur J Nutr 2012 51:261-279)
  15. 14 Ancient Minerals, by enviromedica, What is Magnesium? How it Functions in the Body
  16. 15 Harvard Medical School, What Grandma Ate, A new study looks at how epigenetic effects are passed down, By JEFF BRIGHT July 29, 2014
  17. 16
  18. 17 Peak Fitness, mercola.com, What Does It Mean to Be Fat Adapted? By Mark Sisson
  19. 17a Primal Blueprint, Mark Sisson WHAT IS THE PRIMAL BLUEPRINT? by Mark Sisson.
  20. 20 PubMed, The discovery of the vitamins. Semba RD.
  21. 21 Nobel Prize.org, Christiaan Eijkman, Beriberi and Vitamin B1
  22. 22 Nobel Prize.org, The Nobel Prize and the Discovery of Vitamins, by Kenneth J. Carpenter

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