Marilyn's Column | March/2017
Topic: Vitamin D, Poor sleep and Chronic Illnesses.
Today's Question: How important is Vitamin D to poor sleep and chronic illnesses?
Answer: Repair and Maintenance. The human organism has evolved DNA repair and DNA protection against oxidation and regeneration using the body's own stem cells. Our bodily stores of Vitamin D are critical to sleep and mitigating many chronic diseases while we sleep. Vitamin D goes into the nucleus of the cell and tells it to make specific proteins. To repair every organ we have to repair every cell. We make cell membranes, cellular scaffolding, cellular transport systems. Ref: Fasting - How it helps our Metabolic Repair System | contributor March/2017
Hypothesis: When all humans lived outdoors most of us slept normally until we got old. Except for infections and injuries medical problems also didn’t begin until we got old. In the 1970’s when air conditioning and sunscreen came we stopped making vitamin D on our skin. When the vitamin D went down our sleep became worse. When the sleep started to fail new problems appeared; sleep apnea, fibromyalgia, chronic fatigue, and irritable bowel syndrome (IBS). Things that were uncommon became common; autism, ADD, infertility, premature delivery, depression, allergies. Diseases that used to appear only in the elderly began to appear in the young; heart failure, atrial fibrillation, stroke, autoimmune disease, arthritis, chronic pain, neuropathy, depression, constipation, insomnia, tremor, balance problems and diabetes, just to name a few. (1,2,3,4)
Fasting | the Normal State for Humans
Fasting is the Normal State for Humans: in the biological world, most organisms exist in a fasting state and Eating is a Stress State. (Note 1,2) During starvation periods and lack of carbohydrate sources (seasonal), the formation of ketone bodies increases dramatically. Prolonged low levels of insulin result in both increased fatty acid release from adipose tissue, and increased amounts of the enzymes required to synthesize and utilize ketone bodies. Ketone fuel is more efficient and has less waste by products. (3,4,5) Modern elite runners are now proving that Ketogenesis Energy provides 50-80 Kcal vs 2-3 Kcal of glucose energy. This makes the human animal an excellent long distance runner.
When you are asleep, you are fasting. Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Fasting and Time-Restricted Feeding, TRF, allows mammals to enter alternative metabolic phases, which rely less on glucose and more on ketone body sources. Both intermittent (IF) and periodic fasting result in benefits ranging from the prevention to the enhanced treatment of diseases.
- There is a metabolic master clock and it resets and turns on and off genes throughout the day. There are internal clocks that regulate organ clocks and body chemistry by regulating 3-6000 gene expressions on a daily cycle. This is approximately 25% of our genes on a clock. Bad diet effects these clocks and time restricted feeding resets these clocks. (24,25,26) (Note 3)
- Restricting feeding is important to DNA repair, and allows the body's immune response to rebuild and repair bodily tissues. Therefore, we are biologically set to an eating cycle that depends on the sun. And for best
results we should at a minimum fast for 12 hours. If we can go 15 hours even better, however, that only leaves a 9 hour time slot to eat. 8-5 then fast, which is hard to do but 8-8, or 7-7 is manageable. Water only otherwise.
Satchidananda Panda - Watching Your Diet: One Click at a Time | May/2016
presents the actual facts of our eating habits. Collected from A New Study
AppTool for Circadian Rhythm: myCircadianClock.org.
- Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism, and bolster
cellular protection. In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. Human trials are about start, but in animals intermittent or periodic
fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis.
Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
Additionally, fasting state to feeding state triggers stem cell regeneration and growth, and has been shown to generate new brain cells. (25) The formation, maintenance and reorganization of synapses are critical for brain development and the responses of neuronal circuits to environmental challenges. (26)
- A circadian rhythm is a roughly 24 hour cycle in the physiological processes of living beings, including plants, animals, fungi and cyanobacteria. Circadian rhythms are important in determining the sleeping and feeding patterns of all animals, including human beings. The study of circadian rhythms is called chronobiology.