Contributor

  Changing Gene expression - Nutrigenomics and Epigenetics


Marilyn's Column | July/2016


Topic: Nutrigenomics and Epigenetics

Do you know what "Nutrigenomics and Epigenetics" can do for you?

These new emerging sciences will allow the individual to practice individual medicine. The Individual must take charge of their own health. The age of Individual Medicine is here, and it will free each individual and allow them to learn and know more than most doctors. (Note: 1)

Nutrigenomics and Epigenetics: There is a great deal of research being done on DNA damage and repair, and chronic diseases related to aging. Understanding Nutrigenonics and Epigenetics meaning On top of Genetics, is critical to the way we absorb and metabolize micronutrients.

Our protein encoding genes are mostly with us for life but other components of our DNA are highly dynamic. Specifically, DNA embodies elements and processes that regulate gene expression. We call these regulatory elements and processes epigenetic ones. They are different in different cell types and organs and evolve with aging.

DNA methylation and epigenetics - passing bad genetic traits on th next generation

Nutrigenomics looks at the influence genetic variation has over micronutrient absorption and metabolism and the biological consequences of this dynamic relationship. Dr. Rhonda Patrick | april/15 (1) Epigenetics is establishing the mechanisms of gene expression and diet. Diet-Gene Interactions, Epigenetics, the Vitamin D-Serotonin Link and DNA Damage | Dr. Rhonda Patrick, february/16 (2,3,4,6) (Note: 1)

DNA methylation is a major epigenetic modification involving the addition of a methyl group to the 5 position of cytosine by DNA methyltransferase to form 5-methylcytosine (5-mC). This epigenetic mark has the power to turn genes on or off and can be inherited through cell division.

High School Science we all know: " ... the Queen Bee is not a Queen until fed Royal Jelly, worker bees construct queen bee cells and the bee larvae are fed Royal Jelly exclusively. As a result of the difference in diet, the queen will develop into a sexually mature female, unlike the worker bees." ... this is Epigenetics at work, our diet effect our genes and offspring.

Good Genes Aren’t Enough new research indicates that in order to keep from passing on traits that might be harmful to our kids, it’s important to keep our DNA healthy. Epigenetic information is passed down not just to the next generation but to future generations. (7,8,9,10) Understanding Intergenerational transmission of genetic changes and traits is Epigenetics.

Each Generation passes on Diet and Life Style Choices to the next generation by DNA markers. These Markers are a dynamics process and yes ... Humans can pass on Bad dietary habits. DNA methylation was the first epigenetic marker to be discovered and it plays an important role in normal human development, aging, tumorigenesis, and other genetic and epigenetic diseases.

Further, DNA hydroxymethylation, was discovered to be involved in controlling gene expression and is a key DNA demethylation process as part of the DNA methylation cycle. Although our genetic information - the Code of Life - is written in our DNA, our genes are turned on and off by Epigenetic switches.

Yes! With proper diet much of the DNA methylation effects can be improved. DNA repair is a major metabolic function. Ref: DNA - Aging, Cancer, Nutrition and DNA Repair.

Causative actions :

  1. The current Refined-Carbohydrate Diet - SAD which we are living, and with modern farming, big-pharma, and the chemical industry, we have been convinced our modern diet is good, it is NOT good. Unfortunately, through epigenetics we can pass these epigenetic modification on to the next generation.
  2. Physicians have abandoned the nutritional approach to patient diagnostics and medicine, simply because they are not trained in nutrition. A key part of the Hippocratic Oath ... I will prevent disease whenever I can, for prevention is preferable to cure... has been forgotten. (Note: 2) Dr. Fettke, Dr. Champ, Dr. Seyfried, Dr. Noakes, Dr. Levy, Dr. Humphries.
  3. The Individual must take charge of their own health. Individual medicine is the responsibility of the patient, and is the purview of the scientific community. Intergenerational transmission of genetic information is the responsibility of the Parent. Medicine today, has no Clue as to what this means.
  4. Big Pharma does not play a role, because, it cost a billion dollars to get a drug through the FDA, there is no money in nutrition (healthy people) for them to recover the costs. But their moribund science, sways governments.
  5. Fortunately, there is Google and a lot of new and old research is on the web. The individual can get their own PhD in medical nutrition therapy (figuratively speaking) at home. Therefore, the individual must be educated to be proactive in driving their own healthy living.

DNA repair is an essential cellular function, (4) which, by removing DNA damaged cells before they mutate, contributes crucially to the prevention of cancer. Interest in the influence of micronutrients on DNA repair activity is prompted by the possibility that the protective effects of fruits and vegetables might thus be explained. Ex. Green leafy vegetables are green because of magnesium [Mg++], and Mg++ regulates over 300 biochemical reactions in the body through their role as enzyme co-factors. They also play a vital role in the reactions that generate and use ATP, the fundamental unit of energy within the body's cells - mDNA. (5) (Note: 3,4)

The Role of Methylation and Epigenetics in "Brain Disorders" is totally new and brain disorder understanding over the last 5 years is equal to the previous 20 years. The Role of Methylation and Epigenetics in Brain Disorders | William J. Walsh, PhD, august/14 (12,13,13a) Methylation patterns in our genome can be profoundly impacted by environmental factors from conception to death.

If you have watched Dr. Patrick's videos, Dr. Rhonda Patrick at www.foundmyfitness.com, you have a glimpse of how to be your own effective medical nutrition therapist. Ex ... Vitamin D really functions as a hormone and controls over 2000 genes by turning them on and off. A simple Vitamin D test, B12, and normally a blood panel will give K and Mg and put you in control, will educate, and give a course of action.

Doctors cannot answer simple nutritional questions, so ... we have no choice but to be our own doctor, besides they just regurgitate the science of others. Very few doctors have additional degrees in the sciences, consequently, in most cases they are using "Big-Pharma" science and training. (Note: 1)

DNA methylation and epigenetics - passing bad genetic traits on th next generation Epigenetics is changing everything and this changes our understanding about the responsibility of this genertation to the next - Example: What Grandma Ate, A new study looks at how epigenetic effects are passed down | Harvard Medical School, by Jeff Bright (14) shows that genes pass on a "Memory" of nutrition. Epigenetic effects are passed down from one generation to the next.

Methylation patterns are major drivers of gene expression that change with aging and exercise profound effects on our health and longevity. Abnormal patterns of methylation have been liked to several human diseases. (10)

There are devices coming on the market whereby you can do a finger prick and get over 1500 protein enzyme and their co-factors. There are a number of testing sites such as 23andMe.com that can provide genetic testing and the patient can get an analysis of Polymorphisms (SNPs, pronounced "snips") (15) in order to make dietary decisions. (Note: 3,4)

 


Notes:

  1. It takes up to 5 years for doctors to acquire information we can get today, and most of it is fed to them through Big-Pharma. Doctors of Medicine just regurgitate what Doctors of Science tell them. They both have PhD's, one is in diagnostic medicine and one is in investigative science. In this day and age The Individual must take charge of their own health. Dr. Rhonda Patrick gives a quick tutorial on tools to make genetic and nutritional decisions. How to Personalize Your Nutrition Based On Genetics | Dr. Rhonda Patrick, March/2015 (16)
  2. "Fire your Doctor, How to be Independently Healthy is a book by Andrew W. Saul, Ph.D., Just what kind of a nut would say that? A health nut, that's who. Here's my question to you: if you are not a health nut, just what kind of a nut would you rather be? 100,000 Americans are killed every year by prescription drugs, properly prescribed and taken as directed. According to Carolyn Dean, M.D., hundreds of thousands are killed by other medical mistakes. Now THAT is nuts!
  3. Most people are deficient in Mg++ because we do not eat enough greens. We need at least 400mg per day, which is equal to 2 ½ cups of cooked spinach. Greens also provide Vitamin K1 (blood), folates, lutein and zeaxanthin (eyes-AMD) ... fiber ( gut-microbiome)... i.e. lots of micronutrients. (17,18)
  4. Deficiency in micronutrients will trigger our survival mechanism and reallocate these Scarce Resources in favor of survivasl as seen in Dr. Ames' - Triage Theory.
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[ + ] Sources and References:

  1. 1 youTube, Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance, Apr/15
  2. 2 youTube, Rhonda Patrick on Diet-Gene Interactions, Epigenetics, the Vitamin D-Serotonin Link and DNA Damage, Feb/16
  3. 3 DNA Repair (Effects of micronutrients on DNA repair, Eur J Nutr 2012 51:261-279)
  4. 4 DNA Repair (Effects of micronutrients on DNA repair, Eur J Nutr 2012 51:261-279)
  5. 5 Ancient Minerals, by enviromedica, What is Magnesium? How it Functions in the Body
  6. 6 Dr. Rhonda Patick at www.foundmyfitness.com Found My Fitness . com,
  7. 7 NCBI PubMed - Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12222-7. doi: 10.1073/pnas.1316740111. Epub 2014 Jul 28. Intergenerational transmission of emotional trauma through amygdala-dependent mother-to-infant transfer of specific fear. Debiec J, Sullivan RM.
  8. 8 Cell - CellPress Nucleus, Volume 161, Issue 6, p1453–1467, 4 June 2015 A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development, Walfred W.C et al.
  9. 9 University of Cambridge - Research, eprogramming of DNA observed in human germ cells for first time
  10. 10 Scitable by Nature Education, The Role of Methylation in Gene Expression, By: Theresa Phillips, Ph.D. (Write Science Right) © 2008 Nature Education
  11. 12 youTube, Epigenetics, The Role of Methylation and Epigenetics in Brain Disorders, presented by William J. Walsh, PhD
  12. 13 TED Talk, Epigenetics and the influence of our genes | Courtney Griffins | TEDxOU
  13. 13a NCBI, Frontiers in Cell and Development Biology, Epigenetics across the human lifespan,Riya R. Kanherkar, Naina Bhatia-Dey, and Antonei B. Csoka.
  14. 14 Harvard Medical School, What Grandma Ate, A new study looks at how epigenetic effects are passed down, By JEFF BRIGHT July 29, 2014
  15. 15 NIH, Genetics Home Reference, What are single nucleotide polymorphisms (SNPs)?
  16. 16 youTube, How to Personalize Your Nutrition Based On Genetics, Dr. Rhonda Patrick, March/2015
  17. 17 The Why Files, AMD: The blinding disease
  18. 18 Namas - Natural Remedies for Health, Beautiful Eyes Begin with Nutrition

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