Hypothesis: Tumor Cell form Social Networks ⇒ Collective action when there is a Quorum.
Dr. Thomas Seyfried challenges the current medical community and points to Dr. Otto Warburg - Nobel Laureate ... as a progenitor of our understanding that cancerous tumors can be looked at as a Metabolic Disease. Dr. Seyfried presents his views with lively and compelling evidence ... Cancer: A Metabolic Disease with Metabolic Solutions - 2016 Conference | Dr. Thomas Seyfried | july/2016. (1,1a,b).
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. Essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. (2,3) Ref: ... Metabolic Model of Cancer.
Normal cells require mitogenic growth signals (GS) before they can move from a quiescent state into an active proliferative state. These signals are transmitted into the cell by transmembrane receptors that bind distinctive classes of signaling molecules: diffusible growth factors, extracellular matrix components, and cell-to-cell adhesion/interaction molecules.
According to Hanahan and Weinberg, no type of normal cell can proliferate in the absence of such stimulatory signals. Many of the oncogenes in the cancer catalog act by mimicking normal growth signaling in one way or another. (3,3a, Hanahan D., Weinberg RA) The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. ... say the authors.
Cancer Cell have six acquired alterations described as the hallmarks of nearly all cancers and included, 1) self-sufficiency in growth signals, 2) insensitivity to growth inhibitory (antigrowth) signals, 3) evasion of programmed cell death (apoptosis), 4) limitless replicative potential, 5) sustained vascularity (angiogenesis), and 6) tissue invasion and metastasis. (3,3a, Hanahan D., Weinberg RA)
Life depends on molecular messaging. Cells and organisms, simple ones like c-elegans and complicated ones like humans, are constantly exchanging internal molecular messages. These messages are critical for articulating development, tissue homeostasis, repairs of various kinds, fighting infectious bacteria and other essential functions of life. (4,5)
Primordial Soup - Human cells have a common ancestry with plants. Cells respond to light by increasing molecules such as growth factors, nitric oxide (NO), reactive oxygen species (ROS), ATP, RNA and DNA. (6,7) (Note 1,2)
Professor Loren Williams of the Georgia Tech School of Chemistry and Biochemistry and his team led the research into the first
assemblies of molecules, known as the
Ribosome, that led to the beginning of life. Today the ribosome converts genetic information, from RNA, into proteins in living cells and this
Engine of Life is still running today.
This image is a Collapsed Tree of Life from Wikimedia Commons: by Tim Vickers, and gives a look at the
huge varieties of life, and the small segment from which both
Plants and Animals were derived.
This is a highly resolved Tree of Life based on completely sequenced genomes. From this genome driven depiction of our family tree it is shown that we are decendents of "Protozoa".
We can see we are right there and kindred with plants, algae, fungi, and best of all ...
Slime Mold. ...
Dr. J. Woodland “Woody” Hastings,
together with scientist Kenneth Nealson, discovered that bioluminescent bacteria could communicate and act as a group; a process Hastings called autoinduction.
This communication mechanism is currently referred to as
Dr. Bonnie Bassler - Princeton, (10,11) has shown that cellular and prokaryotic life has had 3 billion years to construct communications for beneficial and defensive pathways. Once cells could communicate Called -Quorum Sensing, they formed collective communities. Humans are just a new/recent - collective of organisms.
Our Gut Microbiome indicates that we are a symbiosis of organized single cells working to form a complex life form, that is itself an organization of specialized cell tissues working as specialized organs, regulatory systems, and control systems ... i.e. a factory that sustains complex life.
Quorum Sensing (QS): The process of cell-cell communication allows cellular communications between cells with chemical signals. This allows cells to collectively work together.
When these Collectives reach a
Quorum they can stimulate a collective response. To humans this looks like an
Attack, but in reality, this collective has its own
Agenda, and unfortunately,
not always beneficial to the host.
Quorum sensing involves the production, release, and subsequent detection of chemical signal molecules called autoinducers. This process enables populations of bacteria to regulate gene expression, and therefore behavior, on a community-wide scale. Quorum sensing research is providing insight into intra- and inter-species communication, population-level cooperation, and the design principles underlying signal transduction and information processing at the cellular level.
Quorums: Forming quorums is a well-established process within bacterial colonies. These quorums can form networks to do combat and defense. Dr. Bassler is "The Bacteria Whisperer", The Secret, Social Lives of Bacteria | Dr. Bonnie Bassler. june/2015 . Quorum sensing is wide-spread in the bacterial world, so understanding this process is fundamental to all of microbiology, including industrial and clinical microbiology, and ultimately to understanding the development of higher organisms.
Metastasis may be a simple
Antagonistic Pleiotropic response made possible when a quorum is formed.
[Williams GC, 1957] This mechanism has been proposed as a theory for aging, and here we
can surmise it as a theory for metastasis.
Our Tools: 1) If we use a LCHF style living as a preventative to abnormal tumor growth, and if prevention fails, 2) then understanding cellular communication by combining genetics, biochemistry, structural biology, chemistry, microarray studies, bioinformatics, modeling, and engineering approaches is possible.
Engineers solve problems, they look atCausesto findSolutions, otherwise buildings collapse ... our health systems will collapse financially, due to man-made diseases which affect Epigenetics, and Future Generations ... "70 Going On 100"
The good news is that these sciences are already in place. We have the best scientific minds already deployed. These scientists love challenges they just
Need the Monetary Support - NIH.
Half of what we know is wrong, the purpose of science is to determine which half " ... Arthur Kornberg, Nobel Laureate - DNA, "The Nobel Prize in Physiology or Medicine 1959"
Ruling Out: If we are ruling out the
Nuclear theory of cancer, then, we need to rule in the
theory with the understanding that
Quorum Expression is now a driving factor. Mutations are not the initiator, the
Quorum is the initiator.
There are several possible Scenarios here -
Antagonistic Pleiotropy. This has already been proposed as an evolutionary explanation for cell senescence. [Williams GC, 1957] We may be seeing that when a
Quorumis formed many gene expression may arise as a collective unit.
Quorum. If we do that, then Managing the 6 hallmarks of Cancers (3,3a, Hanahan D., Weinberg RA) , becomes a control mechanism by which cancer cell communications can be interrupted and stopped. This will allow the immune system to then recognize and take back control. This will allow the immune system to re-gain control, and also allow other Immunotherapy - Biologic Therapy to succeed. (Note 3)
exponential powerrequirements: In 1000 years humans will require the entire energy output of the Sun.
Dark Matteras all the other advanced societies will by now, have surrounded there entire sun with a solar absorbers. Complete networks of these now Dark Suns are hidden from detection. Especially, since it will only takes 1000 years AC (After Cloud). There must be millions of these networks by now.
Dr. Tan is introducing Veterans with advanced cancer to a ketogenic LCHF - (high-fat, adequate-protein, low-carbohydrate) diet. This eating plan starves cancer cells while still meeting a patient's nutritional needs.Take Action
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