Insulin Resistance - a Metabolic Disease made by man ...

Prof. Michael A. McGerk III | July/2017

Topic: Hypothesis: - Part 1,

Insulin Resistance - a Metabolic Disease

Dr. Thomas Seyfried challenges the current medical community and has compelling evidence ... Cancer: A Metabolic Disease with Metabolic Solutions - 2016 Conference | Dr. Thomas Seyfried | july/2016. (1,1a,b) This same thinking can be applied to Insulin Resistance as we have created our own Addiction = Hyper Palatable Foods. Food Engineers have done their job and created modern food that are more Palatable and Sweeter ("Less Fiber" - "Less Bitter") to satisfy our pleasure center, e.g. our benzodiazepine and opioid systems (Brain). (2,3,3a) It is reported that almost 50% of Americans (JAMA-2016) are "Pre-Diabetic" which by definition contradicts eating carbohydrates. The Low Fat - SAD has failed. (4,4a)

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all modern diseases, i.e. Man-made. Essentially these man-made diseases are all hallmarks of insulin overload manifested as Dr. Raven's Syndrome X. (5,6) Ref: ... Insulin Resistance - root cause of Chronic Inflammation.

Insulin Resistance (IR) | a Metabolic Disease we can cure.

What happens to your blood sugar if you eat a Standard American Breakfast? by Amanda Akesson and Dr. Ted Naiman -
Metabolic Overloading of Nutrition pathways and Hormone function is the - Root Cause of Insulin Resistance
Images done by Dr. Naiman's 9 year old daughter for school.
Dietary Responses - Dr. Naiman makes many good points on Insulin Resistance, we reference the work of these writers and doctors from, Amanda Akesson and Dr. Ted Naiman. (3)

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This image is a simple "Science Project" demonstration of the body's reaction to carbohydrate intake. If we eat carbohydrates 20-50 times a day as many humans do on the SAD, then this becomes an abnormal condition. This constant "Yo-Yo" response eventually has a deleterious effect on human metabolism. The Rub ...

Dr. Ted Naiman tweeted about his 9 year old daughter's science project ... My 9-year-old daughter just documented it last week for her science fair. All it takes is a glucometer and some 'crap cereal and skim milk'. (Irony 1,2)

Surprise, when people have high blood sugar they also have high insulin, how is that possible? Insulin is a powerful metabolic hormone that orchestrates how cells process vital nutrients. Insulin is the body's fat storage hormone and signals storage into adipose tissue. Insulin resistance is a physiological condition in which cells fail to respond to the normal action of the hormone insulin. (org, Rub)

The body produces insulin, in response to glucose intake. If blood sugar and insulin spike too high too often, cells will try to protect themselves from overexposure to insulin’s powerful effects by toning down their response to insulin becoming “insulin resistant”. The cells in the body become resistant to insulin and are unable to use it as effectively, leading to high blood sugar. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. (RubADub, RubADub-Dub)

People with Insulin Resistance are normally diagnosed with pre-diabetes and often have slightly higher levels of inflammation throughout their bodies. 49%-52% in the USA are now pre-Diabetic or Diabetic [Menke A, et al. JAMA, 2015]


Insulin Resistance | Diet Driven Diseases

The root cause of Insulin Resistance - System Wide Metabolic Dysfunction, is the High Carb diet refered to as the SAD.
Man-made Diseases, the Medical consequences of a High Carbohydrate Diet - (.PPT presentation.)

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Modern Society created a nutritional disease; therefore, we need a nutritional solution. But, doctors are not trained in nutrition, medicine as we know it is in trouble, can we be better doctors than the AMA provides. We certainly can acquire the knowledge to ask better questions. The AMA has failed in their mission. Dr Noakes gives a good talk on the problem ... The Great Diet Controversy: UCT - Challenge Beliefs Dr. Tim Noakes | november/2013 (12) and Dr. Mercola & Dr. Greger on How Not To Die December/2015 (13)

Our biggest challenge is ourselves and our predilection to eating for flavor, palatability, and desires, neglecting what our bodies are telling us and really need. We are addicted to sugars, white flour, processed foods, smoking and drugs, and overcoming those addictions is the challenge. In the 1960, just after WWII, the first warning were being reported in the news about the Refined-Carbohydrate Disease.. [Cleave TL, et al., 1974] (14,15)

The good news is that these human sciences are already in place. We have the best scientific minds already deployed. These scientists love challenges they just Need the Monetary Support - NIH.

Half of what we know is wrong, the purpose of science is to determine which half " ... Arthur Kornberg, Nobel Laureate - DNA, "The Nobel Prize in Physiology or Medicine 1959"

Engineers solve problems, they look at Causes to find Solutions, otherwise buildings collapse ... our health systems will collapse financially, due to man-made diseases which affect Epigenetics, and Future Generations ... "70 Going On 100"


    Insulin Resistance (IR) is the result of a bad diet -

  1. leads to Insulin Resistance on both paths. Metabolic Dysfunction, like type 2 diabetes is a practical result. It is fundamentally a disorder of insulin signaling - hence, we end up with Metabolic Syndrome - aka Insulin Resistance. It is triggered by the carbohydrate content of the diet. (10,10a)
  2. clearly produces the worst results, leading to Insulin Resistance (IR). Dietary refined grains, starches, and sugars Dysregulation of insulin signaling Excess fat accumulation, obesity, and the obesity Epidemics, aka The Saccharine Disease, Conditions caused by the Taking of Refined Carbohydrates, such as Sugar and White Flour. [Cleave TL, et al., 1974] (14,15) What we observe is that everyone responds to Excess Refined Carbohydrates differently. Some people have a Tolerance, but most "Do Not", and we can see this by the rise in Type 2 and Type 3 (aka Diabetes of the Brains "Alzheimer's") diabetes, obesity, and chronic inflammation diseases. (16,17)


Irony Notes:

  1. When the hero Achilles was an infant, his sea-nymph mother dipped him into the river Styx to make him immortal. But since she held him by one heel, this spot did not touch the water and so remained mortal and vulnerable, and it was here that Achilles was eventually mortally wounded. Today, the tendon that stretches up the calf from the heel is called the Achilles tendon. But the term Achilles' heel isn't used in medicine; instead, it's only used with the general meaning "weak point"—for instance, to refer to a section of a country's borders that aren't militarily protected, or to a Jeopardy contestant's ignorance in the Sports category. Our week point is

    Hyper-Palatables Foods = Sugar = Cocaine = Dopamine

    Addictive Path as described by Dr. Pamela Peeke. Her book The Hunger Fix, describes the body's built-in reward system, driven by the chemical dopamine. Science now shows that you may actually be addicted to certain “hyperpalatables” which are typically sugary/fatty/salty refined and processed food combinations. Whole foods are rarely to blame.
  2. Ironically, all that was needed was to stop processing grains. White flour and white sugar could be shipped and stored for month, thus improving shelf life. Nothing would eat it, as no nutritional value was left. Convenience can be a down fall with unwanted side effects, and not always the best solution. Ref: ... the Obesogenic Diet, and ... the Centenarian Diet.


  1. Our own FDA (20,23) (Some are calling it Fraud and Death Administration) which is supposed to protect its citizens, is influenced by Big-Pharma and The Chemical Industry, something Rockefeller (21,22) started in the 19th century. In the early 20th century the U. S. Supreme Court found John D. Rockefeller guilty of corruption, illegal business practices and racketeering. (22) These institutions had become missionaries of a new breed of companies: the manufacturers of patented, synthetic drugs. This same practice went on in Europe with I.G. Farben cartel - BASF, Bayer, et al. (24,25)
  2. Longevity and the triage theory of nutrients The discovery of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk originally coined the term “vitamines” from the Latin vitals (vitally important) and amines (organic derivatives of ammonia). The major period of discovery began in the early nineteenth century and ended at the mid-twentieth century. (26) The puzzle of each vitamin was solved through the work and contributions of epidemiologists, physicians, physiologists, and chemists. We all know the discover of the cure to Scurvy, and Vitamin C, also, beriber (B1), (27) rickets, pellagra (B3), and xerophthalmia as specific vitamin deficiencies. Many Nobel Prizes came out of the research on vitamins, there discovery, isolation, synthesis and structure. (28)
  3. Opioids attach to receptors in the brain. Normally these opioids are the endogenous variety that are created naturally in the body. ... Dopamine is a neurotransmitter present in regions of the brain that regulate movement, emotion, cognition, motivation, and feelings of pleasure.


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Dr. Tan is introducing Veterans with advanced cancer to a ketogenic LCHF - (high-fat, adequate-protein, low-carbohydrate) diet. This eating plan starves cancer cells while still meeting a patient's nutritional needs.

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[ + ] Sources and References:

  1. Cleave TL, 1974 The Saccharine Disease aka, Refined-Carbohydrate Disease, The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, by Thomas L. Cleave.
  2. org The Noakes Foundation, Our goal is to support the dietary revolution that will reverse the global epidemics of obesity and type 2 diabetes mellitus (DM).
  3. Rub youTube Nutrition Forum - Dr. Donald Layman, PhD, june/2013.
  4. RubADub Crain Medicine, Ancestral Knowledge for a Modern World, A Spoonful of Sugar Helps the Medicine Go Up! DAVID HASTINGS LLOYD, feb/2015
  5. RubADub-Dub youTube, Eric Westman, MD, MHS -- LCHF Treatment of Diabetes, jul/2015
  6. 1 youTube, Cancer: A Metabolic Disease With Metabolic Solutions, Dr. Thomas Seyfried. mar/15
  7. 1a Boston College - Biology, Professor Thomas Seyfried - Cancer as a Metabolic Disease.
  8. 1b Travis Christofferson, author of the phenomenal book, "Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure."
  9. 2 NCBI PubMed Nutr Rev. 2003 May;61(5 Pt 2):S5-9. Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  10. 3 .pdf OnlineLibrary - Wiley, .pdf Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  11. 3a The New York Times – Sunday Review What Cookies and Meth Have in Common? Richard A. Friedman MD, Professor Cornell Medicine – Psychiatrist, Jun/2017
  12. 4 NIH, National Institue of Diabetes, Digestive and Kidney Diseases, Prediabetes and Insulin Resistance, What is insulin?
  13. 4a Diagnosis Diet, Dr. Georgia Ede, How to Diagnose, Prevent and Treat Insulin Resistance.
  14. 5 PubMed, DOI: 10.1373/clinchem.2005.048611 Published May 2005 [PubMed] The Metabolic Syndrome: Requiescat in Pace, Gerald M. Reaven.
  15. 6 Clinical Chemistry, DOI: 10.1373/clinchem.2005.048611 Published May 2005 The Metabolic Syndrome: Requiescat in Pace, Gerald M. Reaven
  16. 10 Dr. Axe - Food is Mecicine, 9 Charts That Show Why America is Fat, Sick & Tired.
  17. 10a American Society for Clinical Nutrition, 2007, Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Richard J Johnson, et al.
  18. 12 University of Cape Town South Africa, The Great Diet Controversy: UCT, Dr. Tim Noakes | november/2013.
  19. 13 Dr. Michael Greger MD, founder of Dr. Mercola & Dr. Greger on How Not To Die (Full Interview), Dec/2015
  20. 14 Precision Nutrition, All about grains: Here's what you need to know. by Ryan Andrews
  21. 15 American Academy of Pediatrics, 1995, The Role of Dietary Fiber in the Development and Treatment of Childhood Obesity
  22. 16 Science Direct, Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice
  23. 17 The Saccharine Disease aka, Refined-Carbohydrate Disease, The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, by Thomas L. Cleave.
  24. 20 Gary Null at the Progressive Radio Network: War on Health - Gary Null's documentary exposing the FDA.
  25. 21 Dr. Rath, Health Foundation, The History of the Pharma-Cartel
  26. 22 Dr. Mercola - Take Control of your Health, Pulling Back the Curtain on the Organized Crime Ring That Is the Pharmaceutical Drug Carte
  27. 23 youTube, TED - Nina Teicholz, Nina Teicholz at TEDxEast: The Big Fat Surprise
  28. 24 Wikipedia, IG Farben was a German chemical and pharmaceutical industry conglomerate.
  29. 25 Dr. Rath Health Foundation, IG Farben and the History of the "Business With Disease"
  30. 26 PubMed, The discovery of the vitamins. Semba RD.
  31. 27 Nobel, Christiaan Eijkman, Beriberi and Vitamin B1
  32. 27 Nobel, The Nobel Prize and the Discovery of Vitamins, by Kenneth J. Carpenter

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