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  Insulin Resistance Part 2 - a Metabolic Disease made by man ...


Prof. Michael A. McGerk III | July/2017


Topic: Hypothesis: - Part 2,

Insulin Resistance - a Metabolic Disease

, every time we spike insulin damage is done to our cells. The Warburg effect Cancer can only use sugar as energy source. Medicine as we know it is in trouble, the AMA and AHA have failed in their mission. Dr. Noakes gives a good talk on the problem ... The Great Diet Controversy: UCT - Challenging Beliefs, Dr. Tim Noakes | november/2013 (Video). WDM's = Coca Cola, Pepsi, Kellogg ... etc. Even 60 Minutes came out against sugar ... the White Death.

those who consume 10% to 25% of their daily calories from added sugar have a 30% increased risk of death from cardiovascular disease compared with those who get less than 10% of their calories from added sugar. Beyond that 25% mark, the risk of death increases three-fold ... (1,2,a,b,c). Today we eat refined sugars (Sucrose and Fructose) in a concentrated form, and, at a rate 50 times that of our ancestors. (3).

 

Insulin Resistance | Diet Driven Diseases

The root cause of Insulin Resistance - System Wide Metabolic Dysfunction, is the High Carb diet refered to as the SAD.
Fig 1 - Man-made Diseases, the Medical consequences of a High Carbohydrate Diet - (.PPT presentation.)

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Modern Society suffers from to much carbohydrates, hence, Carbohydrate Intolerance and Inflammation | contributor february/2017. The human animal was never intended to metabolize glucose/glycogen in large quantities, instead we metabolize and store fats. Insulin is a very weak hormone and just barely can regulate 100mg/dl in our blood. Fat-adaptation is the normal, preferred metabolic state of the human body. Sugar-dependency is an abnormal metabolic state that inevitably leads to insulin resistance and chronic disease. (4,5)

Being able to mobilize and oxidize stored fat during exercise can reduce an athlete's reliance on glycogen. This is the classic "train low, race high" phenomenon, and it can improve performance, save the glycogen for the truly intense segments of a session, and burn more body fat. Ref: ... Hypothesis - Flight or Fight Response | contributor october/2016

People who are on a High Carbohydrate Diet will have many different dietary triggered diseases. Humans have hybridized foods for the last 10,000 years in favor of Palatability and Sweetness ("Less Bitter") e.g. our benzodiazepine and opioid systems (Brain). (14,15,a,b,c) It is reported that almost 50% of Americans (JAMA-2016) are "Pre-Diabetic" which by definition contradicts eating carbohydrates. The low fat diet has failed, it is time for a LCHF eating lifestyle.

has created its own demise by creating Man-made ailments that are driving cardiovascular failure, blood metabolism failure, immune system malfunction, Neurodegeneration, Cancer - a metabolic disease, Insulin resistance (IR), and diseases such as "Type 2" diabetes and Type 3 diabetes (Alzheimer's - Diabetes of the Brain). Functionally all of these can be traced to Inflammation and Insulin Resistance and Modern Malnutrition. (Note: 1,2,3)

 

 

Ok - Now What?

no one is fooled when people use the word Diet. It conjures up thoughts of Restricting our Eating. But, what is the real purpose of a "Diet"? ... the Centenarian Diet is a .

    Goals are Simple:

  1. Optimize our Metabolism for the Future, OMG - We cannot get to the Future "Sick".
  2. Maximize a balance of Nutrients with Food Intake.
  3. Balance Metabolism and Our Bodies will Just Do Its Thing.
  4. Avoid the Following ...
The root cause of Insulin Resistance - System Wide Metabolic Dysfunction, is the High Carb diet refered to as the SAD.
Fig 2 - Science in Evidence, Man-made causes of Compensatory Hyperinsulinemia - (.PPT presentation.) (10,10a)

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is manifested as shown. It reflects all modern diseases of Hyperglycemia, Hyperinsulinemia, Inflammation, and Dyslipidemia (HHID).

The root cause of Insulin Resistance - System Wide Metabolic Dysfunction, is the High Carb diet refered to as the SAD.
Fig 2 - Science in Evidence, Man-made causes of Compensatory Hyperinsulinemia - (.PPT presentation.)

| Open diagram in new window |

Professor Reaven: … the metabolic syndrome (today - a.k.a. insulin resistance) must be considered not in pathophysiologic terms, but as a pragmatic approach to obtain a better clinical outcome in an effort to acknowledge the importance of resistance to insulin action, and its consequences, as increasing the risk of cardiovascular disease (CVD).(10,10a)

 

    Insulin Resistance (IR) is the result of a bad diet -

  1. Cellular Degeneration underlies biological aging and is the Master Disease. Can we cure this? Cancers, cardiovascular degeneration, neurodegeneration of brain and our nervous systems are symptoms of this aging disease. But, we can take action independent of our medical system to catch up.
  2. containing large amounts of sugar, refined flour, and polyunsaturated omega-6 oils are greatly depleted of a wide range of vitamins and minerals. Dr. Ames' Triage Theory predicts that even a marginal deficiency of some of these micronutrients may play a major role in the pathogenesis of CHD. In addition, some components of processed food, such as trans fatty acids, heated vegetable oils and sucrose, may have a direct toxic effect on the cardiovascular system.
  3. have created their own demise by creating Man-made ailments that are driving cardiovascular failure, blood metabolism failure, immune system malfunction, neurodegeneration, cancer - a metabolic disease, and insulin resistant diseases such as Type 2 diabetes and Type 3 diabetes (Alzheimer's - Diabetes of the Brain). Functionally all of these can be traced to Inflammation and Insulin Resistance and Modern Malnutrition

 


Notes:

  1. It takes up to 5 years for doctors to acquire information we can get today, and most of it is fed to them through Big-Pharma. In this day and age The Individual must take charge of their own health. Dr. Rhonda Patrick gives a quick tutorial on tools to make genetic and nutritional decisions with. How to Personalize Your Nutrition Based On Genetics | Dr. Rhonda Patrick, March/2015 (A, B)
  2. Longevity and the triage theory of nutrients The discovery of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk originally coined the term “vitamines” from the Latin vitals (vitally important) and amines (organic derivatives of ammonia). The major period of discovery began in the early nineteenth century and ended at the mid-twentieth century. (20) The puzzle of each vitamin was solved through the work and contributions of epidemiologists, physicians, physiologists, and chemists. We all know the discover of the cure to Scurvy, and Vitamin C, also, beriber (B1), (21) rickets, pellagra (B3), and xerophthalmia as specific vitamin deficiencies. Many Nobel Prizes came out of the research on vitamins, there discovery, isolation, synthesis and structure. (22)
  3. Opioids attach to receptors in the brain. Normally these opioids are the endogenous variety that are created naturally in the body. ... Dopamine is a neurotransmitter present in regions of the brain that regulate movement, emotion, cognition, motivation, and feelings of pleasure. (23,23a,24)

 


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[ + ] Sources and References:

  1. Cleave TL, 1974 The Saccharine Disease aka, Refined-Carbohydrate Disease, The Saccharine Disease, Conditions Caused by the Taking of Refined Carbohydrates, by Thomas L. Cleave.
  2. Video youTube, The Great Diet Controversy: UCT taught me to Challenge Beliefs, Dr. Tim Noakes.
  3. A youTube Dr. Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance
  4. B youTube, How to Personalize Your Nutrition Based On Genetics, Dr. Rhonda Patrick, March/2015
  5. R1 PubMed, Effects of micronutrients on DNA repair. Collins AR, Azqueta A, Langie SA.
  6. 1 Mind, Body, Spirit, bewellbuzz.com, Could Added Sugar Be Affecting Your Blood Pressure?
  7. 2 NCBI, PMC, Are refined carbohydrates worse than saturated fat? Frank B Hu,
  8. 2a Diagnosis Diet, Dr. Georgia Ede, What You Need to Know about Sugar and Insulin Resistance
  9. 2b Dr. Axe - Food is Mecicine, 9 Charts That Show Why America is Fat, Sick & Tired.
  10. 2c American Society for Clinical Nutrition, 2007, Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Richard J Johnson, et al.
  11. 3 Dr. Mercola article and video, Sugar May Be Bad, But This Sweetener Called Fructose Is Far More Deadly
  12. 4 Peak Fitness, mercola.com, What Does It Mean to Be Fat Adapted? By Mark Sisson
  13. 5 Primal Blueprint, Mark Sisson WHAT IS THE PRIMAL BLUEPRINT? by Mark Sisson.
  14. 10 PubMed, DOI: 10.1373/clinchem.2005.048611 Published May 2005 [PubMed] The Metabolic Syndrome: Requiescat in Pace, Gerald M. Reaven.
  15. 10a Clinical Chemistry, DOI: 10.1373/clinchem.2005.048611 Published May 2005 The Metabolic Syndrome: Requiescat in Pace, Gerald M. Reaven
  16. 14 NCBI PubMed Nutr Rev. 2003 May;61(5 Pt 2):S5-9. Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  17. 15 OnlineLibrary - Wiley, .pdf Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  18. 15a New Yori Times, Richard A. Friedman MD, Professor Cornell Medicine – Psychiatrist, Jun/2017. What Cookies and Meth Have in Common?
  19. 15b NIH, National Institue of Diabetes, Digestive and Kidney Diseases, Prediabetes and Insulin Resistance, What is insulin?
  20. 15c Diagnosis Diet, Dr. Georgia Ede, How to Diagnose, Prevent and Treat Insulin Resistance.
  21. 20 PubMed, The discovery of the vitamins. Semba RD.
  22. 21 Nobel Prize.org, Christiaan Eijkman, Beriberi and Vitamin B1
  23. 22 Nobel Prize.org, The Nobel Prize and the Discovery of Vitamins, by Kenneth J. Carpenter
  24. 23 NCBI PubMed Nutr Rev. 2003 May;61(5 Pt 2):S5-9. Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  25. 23a .pdf OnlineLibrary - Wiley, .pdf Brain mechanisms of sweetness and palatability of sugars. Yamamoto T.
  26. 24 The New York Times – Sunday Review What Cookies and Meth Have in Common? Richard A. Friedman MD, Professor Cornell Medicine – Psychiatrist, Jun/2017

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