Personalized diet and responses to food based on genetics ...

Prof. Michael A. McGerk | March/2017

Topic: Personalized Nutrition - Personalize diet and food responses based on genetics ...

will lead to and will allow costs to decline. Finger-prick lab tests are almost here ... and everyone will be able to monitor their Health Parameters from a smart phone. Self-diagnosing will soon to be a reality for pennies on the dollar. So, we really need to start learning how to control our Health and Diet. Dr. Daniel Kraft - TED Talk: Medicine's future? There's an app for that.

Duh, folks we have a Duh Moment (DM). After 104 years, from Harvard T.H. Chan - School of Public Health (1) we have this bit of wisdom ... Precision Nutrition: Can nutrigenomics testing lead to improved diet quality and better health outcomes?
... Precision medicine - tailoring drugs and therapies to a person’s genetic profile - has been touted in recent years as a way to maximize the benefits of treatment while minimizing side effects. Experts are now wondering if personalizing an individual’s diet according to their DNA profile - called precision nutrition - can also improve health ... says Dr. Hu.

Ref: ... Nutrigenomics and Epigenetics | contritutor jul/2016

In a 2015 study by researchers in Israel, the researchers analyzed data from 800 study participants - including data on gut microbiota, which play a key role in diet and health - and developed an algorithm that predicts how much an individual’s blood glucose level might increase after a particular meal. The results showed that a dietary intervention based on the algorithm helped participants significantly lower their typical post-meal blood sugar spikes. (1,2)

Dietary intake is a central determinant of blood glucose levels, and thus, in order to achieve normal glucose levels it is imperative to make food choices that induce normal postprandial (post-meal) glycemic responses (PPGR; Gallwitz, 2009 - Diabetes Care). (3)

    Dr. Hu points out some of the implications of Precision Nutrition. (1,2)

  1. Personalized diets to smooth blood sugar spikes showed positive and an algorithm to describe this was created.
  2. Beverages, epidemiological studies have suggested that coffee is beneficial to health outcomes like type 2 diabetes; more recently, genetic analyses have shed light on the biology behind coffee’s health effects.
  3. Gene and diet interactions - Case for Carbohydrate Sensitivity - A 2012 study led by former Harvard Chan assistant professor Lu Qi showed that people carrying more obesity gene alleles were more susceptible to increases in body mass index from drinking sugar-sweetened beverages than were those with fewer obesity gene alleles.
  4. Microbiota and obesity - Fecal matter transplanting, studies show that with two mice populations, transplanting from an obese human into a group of lean mice - the mice that got the transplant from the obese human became obese. The other mouse group stayed lean. “This suggests that gut microbiota may play an independent role in obesity,” ... Hu said. But, we know this from our growing understanding of Nutrigenomics and Epigenetics | contributor july/2016 and how our Gut Microbiome functions.
  5. Metabolite signatures of diet - Scientists are also using sophisticated analytical techniques to learn more about metabolites - small molecules that are products of metabolic reactions in cells. The analytic techniques are known as “metabolomics”; a person’s “metabolome” is the entirety of metabolites in his or her body. Some studies have shown that certain foods and certain diets have unique metabolic signatures, and researchers are beginning to assess the relationship between these signatures and diseases such as diabetes and cardiovascular disease.

The problem with some of Dr. Hu's conslusions, is that, they have been known for the last 5 years. For example, fecal tranplanting reasearch is part of the gut microbiota which accounts for an estimated 80% of our immune system activity.

- Daniel Kraft - Physician and Scientist is faculty chair for the Medicine and Exponential Medicine program at Singularity University. He points out that Exponential Medicine, which is the future of medicine, and its affects can be enhanced by utilizing:

  1. Low-Cost Gene Analysis
  2. Computational bio-Infomatics
  3. Internet Connectivity
  4. Social Networking

Ray Kurzweil has proposed the Exponential Growth Factor and its effects on our lives. Dr. Kraft outlines innovations in medicine, powered by new tools, tests and apps that bring diagnostic information right to the patient's bedside.

The good news is that Medicine will change and doctors will have much more information and can explore the impact and potential of rapidly developing technologies as applied to health and medicine. This will benefit patients.

will give tools to the patient and will allow costs to decline. Finger-prick lab tests are almost here ... and everyone will be able to monitor their Health Parameters from a smart phone. Dr. Daniel Kraft - TED Talk: Medicine's future? There's an app for that.


Soon we'll cure diseases with a cell, not a pill

  1. Personalized Nutrition - will allow each individual to make better decisions. It is a question of learning and training. Individuals still have to believe enough to change eating habits. Industrialized food manufactures will have to accept the inevitable.
  2. Personalized Medicine - will be based on an understanding of genetic traits, our inherited epigenetics, and the metabolic pathways that allow our sells to live and reproduce successfully.

, and it is a Metabolic disease. Currently there is no real medicine that posptones or slows down this metabolic aging disease. We discuss the future of medicine What is the Future of Nutrition, and is it Important? | contributor feb/2017 and even if there is a cure for aging it is still in the future.

According to Aubrey de Grey the gerontology approach is massively complex. Audrey thinks of aging in the terms of "Repair and Maintenance" as that approach really works and he discusses this in a talk at google ... Aubrey de Grey: "Ending Aging" | Talks at Google | April/2014 and the short form ... Seeking immortality: Aubrey de Grey at TEDxSalford | March/2014

    The "How" of Preventative Maintenance - the 4 "R's"

  1. Replace - when cells atrophy, we need to insure that the stem cell replacement and cell division mechanisms are funtional, this is an area of extensive research.
  2. Remove - the body's Nutrition Immunity system is an important function of the immune system response that actively kills pathogens, turns on Suicide Genes, rebuilds Telomerase/ALT gene deletion plus stem cell reseeding. Eliminating Death-resistant cells, such as cancers. Clean up junk, such as cardiovascular plaque.
  3. Repair - stiffening of arteries and chemical matrixes that are at damaging. Even "Teeth" as it turns out can be repaired by our own stem cells.
  4. Reinforce - this can be as simple as nutrition but with the SAD at work, we see that this is not simple. Making our cells "Robust" is our aim. Division-obsessed cells like cancers need to be stopped, mitochondrial mutations found and sent to repair.


Ok - Now What?

which ever option you want to use, you cannot get there if you are sick. Nutrition is Important, if you want to get to the future to benefit from these new technologies you need to optimize your nutrition now - OMG - You can not get to the future Sick.

We have discussed Metabolism and many Damage Control Pathways on this site 70GoingOn100. We want to work on our Health and Nutrion and Health Span will take care of itself, a healthy lifespan.

are the primary effort of every living animal on this planet. Even plants must seek nutrition and fertile soils with a living microbiome - soil health | contributor april/2016, to thrive. Humans are no different, as we sometimes forget why we eat. We carry our own microbiome - guts and are seeking Energy for survival, and Nutrition for growth and disease control. Supplying the body with proper nutrition is our reason for eating. D. S. McGerk - Why do we eat? | contributor, april/2016. ... Dr. Jeanne Sept - What's Cooking? The Meat and Potatoes of Human Evolution | july/2013. Dr. Richard Wrangham - ... Catching Fire: How Cooking Made Us Human | february/13. The rise of Omega 6 fats, and where did the Omega 3's go from our food sources D. S. McGerk - Fat and Oil in modern diets | contributor, may/2016

What path are You On?


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