Skin - and Health

  Key to Cell health and Metabolism ...


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Skin - and the Centenarian Diet

Living to 100 with healthy skin

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The skin, along with hair and nails, is the protective covering of the body. In addition, the skin prevents germs from entering the body and damaging internal organs. Skin supports the life of all other body parts and plays a role in maintaining the immune system.

While skin appears to be a mere covering of our body, it is best thought of as an immune organ and our first line of defense. It protects us from microbes and the elements, helps regulate body temperature, and permits the sensations of touch, heat, and cold.

As our first line of defense, it also give us the first signs that something is affecting our immune system. (1) Vitamin D is vital to our immune system.

When exposed to the sun's ultraviolet rays, the skin manufactures Vitamin D, an essential vitamin for healthy skin. Vitamin D promotes the body's absorption of calcium, which is essential for the normal development of healthy teeth and bones.

, skin plays a large role in manufacturing Vitamin D which with Vitamin K is vital to bone health, skin health, eyes and many biological functions in humans. UCTV, Science and Dermatology: More than Skin Deep | by Dr. Jenny Kim | september/11, Dr. Kim discusses skin immunity and the sophisticated protective mechanisms that keep us healthy.

is an important function of the immune response that actively kills pathogens. This mechanisms limits nutrient availability to the pathogen. New research shows interleukin-22 (IL-22) plays an essential role in resolution of infections at epithelial barrier sites, including skin, lungs, and intestines. [Sakamoto et al.] Point here is - Keep your liver healthy and your skin will love it | contributor February/2017(2)

 

Omega-3 and Healthy Skin

One of the most important thing we can do to is bring our fatty acid consumption back to a ratio more near out ancestors'. Today, most people are eating too many Omega-6 fatty acids and this distorts the Omega-6 to Omega-3 ratio. This distortion of polyunsaturated fatty acids may be a factor in the standard western diet (SAD) that is causing inflammatory diseases.

Living to 100 with healthy skin

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Fig 1 of 22. Linus Pauling Institute - Essential Fatty Acids and Skin Health

Certain foods have powerhouse ingredients that keep skin supple and smooth and help fight age-related damage, says Nicholas Perricone, MD, a board-certified dermatologist and author of Ageless Face, Ageless Mind. Wondering what to eat and what to smooth on? These skin-saving foods help both ways. Essential oils are also important for the skin. Bastyr University is a teaching clinic and presents a technical lecture on Living Naturally - Healthy Skin Through Better Nutrition | by Phoebe Yin, ND | september/11.

How does the skin work? (5) Among the must-have foods for healthy skin: Want Healthy Skin? Feed it Well, (6) omega-3 fatty acids -- the "good fats" that have recently been credited with increasing heart health as well as helping your skin look healthier. The foods highest in omega-3 fatty acids include seafood (especially trout and salmon) as well as walnuts, and flax seeds and oil. Ref: ... this site - Healthy Fats and Centenarians.

Living to 100 with healthy skin

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The body's metabolism produces ROS and our own immune responses can clean these up. Our body uses Antioxidants from food sources to make this happen. Shortages in macro and micro nutrients break this immune response and our bodies cannot respond, triggering reallocation of resources. Ref: ... Triage Theory. Also, our modern world and (SAD) compound this.

, (6) antioxidants are important to slowing and preventing free-radical damage. You can find them in all kinds of foods, especially colorful fruits and vegetables like berries, tomatoes, apricots, beets, squash, spinach, sweet potatoes, tangerines, peppers, and beans. Ref: ... this site Polyphenols - Phytonutrients.

Berries have more anti-aging vitamin C per serving than oranges or grapefruit. Actually Green Peppers are the Highest Source, and, research published in the American Journal of Clinical Nutrition shows that people who eat foods rich in vitamin C have fewer wrinkles and less age-related dry skin than those who don't. Vitamin C fights free radicals, which damage cells and break down collagen, leading to fine lines.

Due to the body's own anti-oxidant immune response it is not the best strategy to take supplements, as they can interfere with our body's own response. Ref: Pre/Post Workout - The body's own Stress Response is far superior to any supplement.

 

Vitamin D - and Healthy Skin

Really a pro-hormone: 1,25 dihydroxy-vitamin D

Vitamin D is actually a "prohormone", which your body produces from cholesterol. Living to 100 with healthy skin Because it is a prohormone, vitamin D influences your entire body. Receptors that respond to the vitamin have been found in almost every type of human cell, from your brain to your bones. (9,10) Vitamin D is vital to our immune system. With proper sun exposure, skin plays a large role in manufacturing Vitamin D vital to bone health, skin health, eyes and many biological functions in humans. Humans have about 27,000 genes, (11) and so far, vitamin D has been shown to influence nearly 3,000 of them.

According to Dr. Michael Holick the skin manufactures from Cholesterol - PreD3, Vitamin D, Suprasterol II, Suprasterol I, Transvitamin D3, Lumisterol-3, Tachysterol-3, and many compounds we do not even know about. If vitamin D influences 3,000 genes then there are many metabolic pathways within the human organism that are affected. Ref: ... this site - Risky Nutritional Supplements and Vitamin D.

The evidence just keeps pouring in that vitamin D is a superstar for your health. Dr. Mercola (12) on his web site, has listed some of the 800 research project currently active on Vitamin D research. Getting proper sun exposure is not a luxury, but a necessity. Your body can make all of the vitamin D you need, 10-20 minutes a day, with 40% of skin exposed = 20,000 IUs. Supplements cannot come close to what your skin can do for you. (12,13)

According to Dr. Michael Holick who has been researching Vitamin D for 40 years and pointing out the errors of the AMA, and FDA is one of the leading authorities on Vitamin D. The D-Lightful Vitamin D for Good Health | Dr. Holick, March/2013 explains some of the hundreds of metabolic pathways and causes of longevity diseases. (15,16a)

for years we have been told to avoid the sun due to the “damaging” effects of UV radiation. The newest research has shown that the sun’s rays do much more good than harm. The sun’s ability to charge our bodies with vitamin D makes it extremely powerful at minimizing free radical damage and maintaining moisture in the skin. Aging and "Healthspan" is absolutely dependent upon healthy sun exposure

Living to 100 with healthy skin

The skin is your first line of defense against pathogenic invaders and is under constant onslaught by the outside environment. In fact, the body must replace approximately 30,000-40,000 skin cells every minute. (16)

Both cholesterol and sulfur afford protection in the skin from radiation damage to the cell’s DNA, the kind of damage that can lead to skin cancer. Cholesterol and sulfur become oxidized upon exposure to the high frequency rays in sunlight, thus acting as antioxidants to “take the heat,” so to speak. Oxidation of cholesterol is the first step in the process by which cholesterol transforms itself into vitamin D3. (Seneff, 17,30,30a)

This process yields Vitamin D sulfate, which is vastly different than plant-based Vitamin D2 and animal-based Vitamin D3.

Upon exposure to the sun, the skin synthesizes Vitamin D3 Sulfate, a form of Vitamin D that, unlike unsulfated vitamin D3, is water soluble. As a consequence, it can travel freely in the blood stream rather than encapsulated inside LDL (the so-called “bad” cholesterol) for transport. The form of vitamin D that is present in both human milk and raw cow’s milk is vitamin D3 sulfate (pasteurization destroys it in cow’s milk). ... this is one of the main reasons for the "Campaign for Real Milk Movement" and the Farm-to-Consumer Legal Defense Fund.

have simply failed to understand what pasteurization does to nutrition and the microbiome in both foods and the human digestive system. The Gastrointestinal Tract (GI) (18 - PubMed Health)

    Conclusions:

  1. Sun exposure is the primary source of vitamin D for most people. (20) The vitamin D made by your body last 3 times longer than supplement vitamin D, the reason is obvious in that there is much more going on with this manufacturing process. (20a,b,c,20d)
  2. Living to 100 with healthy skin In vitamin D deficiency, calcium absorption cannot be increased enough to satisfy the body's calcium needs. (30) Before taking vitamin D you should test your vitamin D blood levels. Test quarterly, but minimum twice a year, and aim for 50 ng/ml. (40-70 ng/ml range) Lifestyle is key, as sun exposure, diet, where on the planet you are, your skin color, and time of year contribute to your health and longevity.
  3. Vitamin D deficiency is associated with an increased risk of developing obesity. (21)
  4. Vitamin D deficiency has been associated with increased risks of cancers, cardiovascular disease, autoimmune diseases, and type 1 diabetes mellitus. (22,23)
  5. Living to 100 with healthy skin Paleo diehards, both men and women, now have a reason to run around "Top-Less". Dr. Mercola has a good article on Vitamin D. Figure 1 is from his article on vitamin D. It should be noted that this represents a very small portion of the total radiation from the sun that reaches the earth's surface. Much is filtered out by our atmosphere and will not penatrate glass. So due to the physics and wavelength of UVB rays it will only penetrate the atmosphere when the sun is above an angle of about 50° from the horizon. When the sun is lower than 50°, the ozone layer reflects the UVB-rays but let through the longer UVA-rays.

 

 

Wound Healing - and Healthy Skin

Vitamin D, Sulfur, and Cholesterol Sulfate

Dr. Stephanie Seneff (30) has accumuated a large amount of scientific data on modern medicine and chemicals that interfere with Human Metabolism. We know that cells in the skin produce Vitamin D3 Sulfate in the skin from Cholesterol and sulfur upon exposure to sun. Sulfur is an essential mineral and deficiencies are prevalent. Cholesterol-Sulfate is a water soluble lipid that is used as a solar energy source in the skin and further processed by the liver and skin. An estimated 2,000 genes interact with sulfated cholesterol, consequently, the metobolic pathways include - Steroids, Lipid metabolism, Cell membranes, Enzyme systems, Skin health, and is part of the sulfolipids such as dehydroepiandrosterone (DHEA) sulfate in blood plasma. (31)

According to Dr. Stephanie Seneff a sulfur deficiency and consequently a cholesterol-sulfate deficiency in the skin leads to Bad Blood and Cardiovascular disease. Vitamin D and Cholesterol-Sulfate protect against cancer, diabetes, cardiovascular diseases, and improve our immune function.

Living to 100 with healthy skin

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Dr. Stephanie Seneff - Importance of Cholesterol and Sulfur in the Diet. (30a)

Sunscreen Does Not Work with a 30-fold increase in the use of sunscreen since 1974, skin cancer has increased 2% each year since then.

Living to 100 with healthy skin

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Dr. Stephanie Seneff - Importance of Cholesterol and Sulfur in the Diet. (30a)

What is going on ... ? Living to 100 with healthy skin

    How to stay healthy.

  1. Plenty of dietary Sulfur.
  2. Plenty of dietary Cholesterol.
  3. Plenty of Sun Exposure.

Cholesterol Sulfate Deficiency leads to filaggrin deficiency (Wiki), atopic dermatitis, esoinophilic esophagitis, and asthma. These conditions are on the rise and are associated with Autism and Celiac disease. (32)

 

 

Psoriasis - and Healthy Skin

Psoriasis, and a connection with year round Chronic Vitamin D deficiency

Our skin has three major layers: the epidermis, dermis and deeper subcutaneous tissue made of fat and connective tissue. It is the growth rate of the epidermis that changes and produces the symptoms of psoriasis.

Psoriasis develops when our body triggers an excessive production of skin cells at the lowest layer of skin. This overgrowth pushes more cells to the top layer of skin that has not yet differentiated enough to slough off our body. This overgrowth is a sign that the skin is stressed and responding to some sort of auto-immune stimulus, and appears to be an abnormality in the function of the immune system.

Living to 100 with healthy skin Dr. Richard Gallo - National Psoriasis Foundation and his researchers have demonstrated a strong track record of successful results when sufferers optimize their vitamin D levels. One study found that many with plaque psoriasis suffer with vitamin D deficiency year-round. Insufficiency was found independent of age, gender, BMI, thyroid hormone levels and time of the year. (35,36)

Interestingly, illnesses commonly associated with psoriasis, such as cardiovascular disease, type 2 diabetes, osteoporosis and metabolic syndrome, are also associated with low levels of vitamin D. (37)

Science has discovered that the synthetic forms of vitamin D will slow the growth of skin cells, one of the hallmark characteristics of psoriasis. However, some of the analogue vitamin D forms are irritating to the skin, making natural production of vitamin D by your body a better option for treatment, and without the side effects of medications. A recent study with 35,000 IU of vitamin D per day as a treatment, provided benefit to 9 out of 9 patients. Vitamin D deficiency is common, especially in North America. (38)

    Conclusions:

  1. There is much more going on in the skin. Sun exposure should be the primary source of vitamin D for most people. (20) The vitamin D made by our body last 3 times longer than supplement vitamin D, the reason is obvious - the manufacturing process in the skin is much more complex and beneficial. (20a,b,c,20d)
  2. Science has discovered that the synthetic forms of vitamin D will slow the growth of skin cells, one of the hallmark characteristics of psoriasis. However, some of the analogue vitamin D forms are irritating to the skin, making natural production of vitamin D by your body a better option for treatment, and without the side effects of medications. (37)

 


[ + ] Sources and References:

  1. University of California Television (UCTV), Science and Dermatology: More than Skin Deep | by Dr. Jenny Kim | september/11,
  2. 1 WebMD - Skin Problems and Treatments Health Center Skin Conditions
  3. 2 Science Immunology, 03 Feb 2017:Vol. 2, Issue 8, IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections, Kei Sakamoto, et al.
  4. 5 PubMed Health - National Library of Medicine How does the skin work? Last Update: February 7, 2013; Next update: 2016.
  5. 6 WebMD - Healthy Beauty Slideshow: Foods for Healthy, Supple Skin
  6. 9 Dr. Mercola, www.mercola.com, Could Optimizing Your Vitamin D Levels Actually Reduce Cancer and Diabetes by 50%? September 06, 2010
  7. 10 PubMed.gov, A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. et al,
  8. 11 Science 2.0, How many genes do you REALLY have? By Michael White | May 6th 2008
  9. 12 Dr. Mercola, www.mercola.com, Journal Articles, Over 800 References Showing Vitamin D's Effectiveness for Cancer
  10. 13 NASW, National Association of Science Writers, Vitamin D levels determined how human skin color evolved, by Jeff Grabmeier on Thu, 02/21/2013
  11. 15 youTube, Dr. MIchael Holick, The D-Lightful Vitamin D for Good Health
  12. 15a PubMed, Vitamin D and inflammatory diseases, Kai Yin and Devendra K Agrawal, 2014
  13. 16 NCBI Bookshelf, Developmental Biology. 6th edition, Gilbert SF, Sunderland (MA): Sinauer Associates; 2000. The Epidermis and the Origin of Cutaneous Structures
  14. 17 Dr. Mercola and Dr. Stephanie Seneff, 2011, Could THIS Be the Hidden Factor Behind Obesity, Heart Disease, and Chronic Fatigue?
  15. 18 PubMed Health, Gastrointestinal Tract (GI Tract)
  16. 20 OSU, Linus Pauling Institute, Vitamin D and Skin Health, "This link leads to a website provided by the Linus Pauling Institute at Oregon State University. We are not affiliated or endorsed by the Linus Pauling Institute or Oregon State University."
  17. 20a youTube, Dr. MIchael Holick, The D-Lightful Vitamin D for Good Health
  18. 20b PubMed, Vitamin D and inflammatory diseases, Kai Yin and Devendra K Agrawal, 2014
  19. 20c PubMed, Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Anderson JL, et al.
  20. 20d theBMJ 2003;327:316, Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study, 2003.
  21. 21 Atherosclerosis Journal, Vitamin D deficiency and obesity, I. Gonzalez Molero, G. Rojo, S. Morcillo, C. Gutierrez-Repiso, E. Rubio, F. Soriguer, F. Soriguer EAS-0668
  22. 22 Focus for Health, Vitamin D: The Sunshine Vitamin
  23. 23 PubMed.gov, Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Holick MF1.
  24. 30 MIT - Dr. Stephanie Seneff, Dr. Stephanie Seneff is a Senior Research Scientist at the MIT.
  25. 30a MIT - Cholesterol Sulfate, Cholesterol Sulfate, by Stephanie Seneff.
  26. 31 JLR - Journal of Lipid Research, Cholesterol sulfate in human physiology, what's it all about? Charles A. Strott and Yuko Higashi
  27. 32 Entropy, 2012 V14, 2492-2530, MIT Archive, Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease Stephanie Seneff, Ann Lauritzen, Robert Davidson and Laurie Lentz-Marino.
  28. 35 National Psoriasis Foundation, How Vitamin D Can Help Psoriasis, 09/10/15
  29. 36 The British Journal of Dermatology, 2012, Vitamin D Status in Patients with Chronic Plaque Psoriasis.
  30. 37 Mayo Clinic, Diseases and Conditions, Psoriasis
  31. 38 NCBI PMC, Dermato Endocrinology, 2013, doi:10.4161/derm.24808 A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis, Danilo C Finamor, et.al.

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