DNA - Repair

  DNA Repair, Longevity Genes, Metabolic Aging and Cancer ...

Track Your Nutrition & Health Data with cronometer.com

Bulk Supplements for nutritional requirements.
Cancer cells move from the quiescent state into an active proliferative state
Acquired GS - Cancer cells move from the quiescent state into an active proliferative state ... tumor cells seem to generate many of their own growth signals, (3a,b)

DNA - and the Centenarian Diet |
Aging, Cancer, Nutrition and DNA Repair

While conventional medicine has little to offer outside the standard 'cut', 'poison', 'burn' approach, new evidence suggests nutritional ketosis could both treat and prevent most cancers. Contrary to conventional teaching, nuclear genetic defects do not cause cancer. Mitochondrial damage happens first (mtDNA), which then triggers nuclear genetic mutations. (1,1a,1b) Mitochondrial dysfunction is at the core of virtually all diseases, and one of the reasons nutritional ketosis works so well is because it boosts mitochondrial function and effectively drives down inflammation. It can benefit a wide array of other diseases, including neurodegenerative diseases such as Alzheimer's and Parkinson's, obesity, diabetes, heart failure, heart disease, and arthritis ..." (2,3)

According to BestAnswerforCancer.org - Patients, ... the death rate for cancer, adjusted for the size and age of the population, dropped only 5 percent from 1950 to 2005. In contrast, the death rate for heart disease dropped 64 % in that time, and for flu and pneumonia, it fell 58 %. (A,B,C) Clearly a failure after 100's of billions spent. Genetic causes is the wrong path ... the NCI has failed to understand the challenge.

Mitochondria are our cells' energy dynamos, and they get flaky as we age. Descended from bacteria that colonized other cells about 2 billion years ago, all cells are more sophisticated than thought. TED Talks: The secret, social lives of bacteria | Dr. Bonnie Bassler. april/09 (Video). And a recent and more detailed review of cell communication and how it may apply to more complex research. Bonnie is "the Bacteria Whisperer", The Secret, Social Lives of Bacteria | Dr. Bonnie Bassler. june/2015 (Video).

A prominent theory of aging holds that decaying of mitochondria, Mitochondrial Dysfunction Dr. Mercola and Dr. Patrick | jan/2016, (1c,1d,2,3) is a key driver of aging. While it's not clear why our mitochondria fade as we age, evidence suggests that it leads to everything from heart failure to neurodegeneration. DNA repair is the issue. Refs ... DNA - Repair, PubMed, DNA Repair - Video.

- which is the process by which new mitochondria are made inside the cells. Many factors can activate this process including exercise, cold shock, heat shock, fasting, and ketones. Moving the metabolism off glucose and away from Glycolysis to Oxidative Phosphorlation drives metabolism to up-regulate mitochondrial machinery, hence Mitochondrial Biogenesis. (2,3) and General Nutrition for Mitochondrial Biogenesis and Cancer Prevention.

The "Triage Theory" proposed by Dr. Bruce Ames, proposes that our body selects short term survival over longevity pathways when there is a shortage of micronutrients Dr. Patrick on Micronutrients for the Prevention of Age-Related Diseases and Brain Dysfunction | june/2016 . Any nutrient shortage will lead to Mitochondrial Dysfunction.

Dr. Mercola's Pledge to Thomas Seyfried - Cancer Support

Cancer as a Metabolic Disease - Aug/2017

Dr. Thomas Seyfried is a proponent of Cancer Prevention and Control by Metabolic Nutrition.

The book Tripping Over the Truth: The return of the Metabolic Theory of Cancer illuminates a nutrition approach to medicine that was known in the 1920's and still use in the Cure and control of Epilepsy. The Charlie Foundation is the leader in LCHF - Ketogenic Therapies for epilepsy.

Dr. Gerogia Ede on Dr. Seyfried's Ketosis for Cancer, as she explains some of the intricacies of apply Dr. Seyfried's Zone of Metabolic Management. His book is based on much science, consequently, not for the novice. We suggest starting with Chris Christofferson's - Tripping Over the Truth: The return of the Metabolic Theory of Cancer

In a NutShell | Processed Foods promote Disease

Chronic Inflammation is a major driver, and our modern processed food diet is highly inflammatory. Key culprits include polyunsaturated fats (PUFAs), trans fats and added sugar in all its forms, especially processed fructose (such as high-fructose corn syrup), as well as refined grains. This is reflected by ... the Centenarian Diet espoused by this site, and the following youtube Videos, Dr. Fettke, Dr. Seyfried, Dr. Christofferson, and Dr. Champ. Dr. Noakes (2,4,10,14,16,17,18,19)

Dr. Gary Fettke -

'A 'Nutritional' model of Inflammation & Modern Disease'

Dr. Gary Fettke, 2014, Orthopaedic Surgeon and Senior Lecturer at the University of Tasmania. Cancer survivor and nutrition researcher. (4)

Dr. Gary Fettke, 2017, Gary's Presentation 2017 CrossFit Health Conference. The Role of Nutrition in Health, Education, Economics, Politics, Environment and Beliefs' at the CrossFit Health Conference, Madison Wisconsin, 2 August 2017.

Travis Christofferson, author of the phenomenal book "Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure."(2,3)

Dr. Thomas Seyfried: Cancer: A Metabolic Disease With Metabolic Solutions. Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.(10)

Dr. Colin Champ: University of Pittsburgh Medical Center where he heads the diet and nutrition division of the Integrative Oncology Department. His research focuses on diet, exercise, and lifestyle optimization for cancer treatment and prevention. (16,17,18)

Professor Timothy Noakes (born 1949) is a South African professor of exercise and sports science at the University of Cape Town. He has run more than 70 marathons and ultramarathons and is the author of several books on exercise and diet. (19)

 

The Metabolic Model of Cancer | The New/Old Frontier

that cancer is not a genetic, but a metabolic disease, we can change our fundamental strategy and address our diet. Diet alone will not solve the cancer riddle. It will likely prevent it. Hippocrates, on Balance and Harmony, and Ames - Triage Theory on Reallocation - Scarce Resources; also, the Chinese Yin and Yang Theory.

When you look at all the science behind cancer, it brings to mind, body, spirit, lifestyle, the immune system, diet and detoxification ... and you had better hope you immune system is running at its peak.

Glucose Metabolism is one of the primary considerations within our mitochondria, a theory initially brought forth by Dr. Otto Warburg - (Video)(wikipedia) in the 1920s. Warburg proposed with scientific insight that irreversible damage to respiration was the prime cause of cancer. He lost out to the theory of Gene Expression. The view of cancer as a metabolic disease was gradually displaced with the view of cancer as a genetic disease. His hypothesis was put in his own words at the 1966 Nobel-laureate meeting ... the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. (Note 1)

In 1931, Warburg won the Nobel Prize in Physiology for Medicine for his discovery that cancer cells have a fundamentally different energy metabolism compared to healthy cells. The nuclear genetic defects typically thought to be responsible for cancer actually occur further downstream. Mitochondrial damage happens first, which then triggers nuclear genetic mutations that may lead to cancer. (2,3) (Note 2)

Dr. Craig Thompson (Memorial Sloan-Kettering Cancer Center) is on record that cancer has the same graphical curve as obesity and the causes are the same Insulin Resistance. Additional glucose corrupts the insulin pathways and reprograms glucose metabolism to fuel cell growth, this is an ancient cell function (before photosynthesis). He discusses this at the 2014 Gairdner Symposium on cancer ... Dr. Craig Thompson - New Advances in the Biology and Treatment of Cancer | november/2014. Conclusion: Metabolites - Glucose and Glutamine - are bad and drive tumor cell energy metabolism and triggers unwanted and never before seen cell activity and mutation i.e. "Wildtype".

Dr. Thomas Seyfried challenges the current medical community and points to Dr. Otto Warburg - Nobel Laureate ... Cancer: A Metabolic Disease with Metabolic Solutions - 2016 Conference | Dr. Thomas Seyfried | july/2016. (10a,b). Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. Essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. (40,40a)

Cancer cells move from the quiescent state into an active proliferative state
Acquired GS - (40a)

| Open image in new window |

Hanahan D., Weinberg RA, (40a) postulate that Cancer Cell have six acquired alterations described as the hallmarks of nearly all cancers. Cancer cells move from the quiescent state into an active proliferative state as tumor cells seem to generate many of their own growth signals. (Note 2)

Dr. Mercola and Dr. Seyfried discuss Cancer as a Metabolic Disease on Dr. Mercola's website ... How the Metabolic View Alters Cancer Treatment. (15,15a,15b) Ref: this site ... Longevity - becoming Centenarians. And, a contributor with a thoughtful hypothesis based on Dr. Bonnie Bassler's work and Dr. Thomas Seyfried's latest paper ... Cancer - Hallmarks and Mechanisms of Metastasis: Hypothesis | contributor march/2017.

Dr. Colin Champ who works with cancer patients, proposes and uses the Ketogenic Diet as a metabolic therapy for cancer ... Colin Champ: Augmenting Cancer Therapy with Diet | november/2014. (16,17) This flow chart shows how the LCHF ketogenic diet blocks the insulin and IGF-1 growth pathways. Essentially using the Warburg Effect to control metabolic states ...

Aging and longevity, using carbohydrate restriction to up-regulate fatty acid oxidation and impair glycolysis as a defense against Cancer.

Calorie restriction (CR) and a ketogenic diet (KD) target the same molecular pathways that are also targeted individually by drugs to improve cancer treatment outcomes. Arrows indicate activation, truncated lines inhibition. Carbohydrate (CHO) restriction up-regulates fatty acid oxidation and ketogenesis (beneficial for normal tissues) and impairs glycolysis and glutaminolysis (detrimental to tumor cells). ..." according to Dr. Champ and Dr. Klement. (18)

Resource Tool: there are many new trials on nutrition and cancer ... and ClinicalTrials.gov - A service of the U.S. NIH is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. Dr. Jeff Volek along with Dr. Stephen Phinney have re-written the Atkins Diet and Dr. Volek explains the LCHF and ... Health-Promoting Effects of a Low-Carbohydrate Lifestyle | July/2016. (20,20a), and from contributors ... Carbohydrates and Longevity | contributor October/2016.

The Additional Recommended Watching ... more


 

Cancer Cells | Metabolically Limited to Feed on Sugar

Dr. Warburg (Wiki) discovered that in the presence of oxygen, cancer cells overproduce lactic acid, and this became known as the Warburg Effect. The Metabolism of Tumors in the Body, Warburg O, Wind F, Negelein E. 1927 (PubMed) (.pdf) So what does this tell us about the nutritional origins of cancer? Warburg's findings tell us that sugar "feeds" cancer while fats "starve" it. Healthy cells can use either glucose or ketone bodies from fat as an energy source, but cancer is metabolically restricted to using glucose only. Cancer cells must ferment, so Dr. Gary Fettke cured his own cancer using a Ketogenic diet as a cure. 'A 'Nutritional' model of Inflammation & Modern Disease' | Dr. Gary Fettke | october/2014. (4)

aging and longevity, becoming a centenarian Curbing Cancer's Sweet Tooth Dr. Jocelyn Tan is counting on a simple diet switch to stop cancer in its tracks. Tan is introducing Veterans with advanced cancer to a ketogenic LCHF - (high-fat, adequate-protein, low-carbohydrate) diet. This eating plan starves cancer cells while still meeting a patient's nutritional needs. According to Dr. Tan ... The ubiquitous sweetener, i.e. - sugar, doesn't cause cancer, but it can feed the disease once it starts. Even more: Without sugar, cancer cells will starve.

Jocelyn Tan, M.D., Keto Oncologist

LCHF is a non-toxic, proactive alternative where patients can say, 'At least I feel like I'm doing something to help myself,' ...
Dr. Tan - Jocelyn Tan, M.D., and Keto Oncologist.

Dr. Eugene Fine, along with long time ketogenic diet proponents such as Dr. Jeff Volek, and his team at Albert Einstein College of Medicine, is a leading researcher in the inhibition of aggressive cancers by an insulin inhibiting ketogenic diet-human trials as well as pre-clinical study. Dr. Fine ... we are also interested in coupling dietary interventions with selected cancer drugs.. Dr. Fine's research centers on the effects of dietary and nutritional manipulation, and especially of reducing carbohydrate content, on altering the metabolic environment. (4a) [Fine EJ, et al.]

 

Quorum Sensing (QS) | A New Frontier

How viruses and bacteria Communicate

Will this lead to new science or antibiotics and medicines.

A process called "QS - quorum sensing," which allows bacteria to work together and control bacterial virulence. Virus's hijack cells and wait and tune into the host until they have a quorum. Then auto-inducers can stimulate a collective attack on the host. Dr. Bonnie Bassler - Princeton, (30) is at the leading edge of cellular and viral collective communication. Bonnie is "the Bacteria Whisperer", The Secret, Social Lives of Bacteria | Dr. Bonnie Bassler. june/2015 (Video).

Quorum sensing and new science for medicines and antibiotics

| Open image in new window |

Quorum sensing involves the production, release, and subsequent detection of chemical signal molecules called autoinducers. This process enables populations of bacteria to regulate gene expression, and therefore behavior, on a community-wide scale leading to complex organisms.

Quorum sensing is wide-spread in the bacterial world, so understanding this process is fundamental to all of microbiology, including industrial and clinical microbiology, and ultimately to understanding the development of higher multi-cell organisms, i.e. "Complex Animals - Humans". (31)

Plaque quorum sensing centenarians Biofilm-formation can lead to infected swollen gums, recession of gums and loss of teeth and accelerated tooth decay.

The 2002 publication Communication among Oral Bacteria (31a), reports Human oral bacteria interact with their environment by attaching to surfaces and establishing mixed-species communities ... such order requires communication.

Life depends on molecular messaging. Cells and organisms, simple ones like c-elegans and complicated ones like humans, are constantly exchanging internal molecular messages. These messages are critical for articulating development, tissue homeostasis, repairs of various kinds, fighting infectious bacteria and other essential functions of life. (32,32b)

EcoOncology - Ecology & Complex Adaptive Systems and how to manage tumors as a biological system. Starting with central tenets of pest management, new therapeutic approaches are being developed to treat aggressive malignant cancers and these approaches are as successful as many standard of care treatments but exhibit reduced toxicity and are simple and cost effective to implement.

Dr. Brent Reynolds coined the term "EcoOncology"", and his research uses the LCHF - Ketogenic diet, and environmental techniques to manage turmors. He explains this approach ... Dr. Brent Reynolds - EcoOncology Applying the Principles of Ecology to Oncology | May/2016.

CRISPR–Cas (clustered, regularly interspaced short palindromic repeats–CRISPR-associated proteins) is part of the adaptive immune systems in prokaryotes (Wiki) . There is mounting evidence that these systems modulate other processes, such as the genetic regulation of group behaviour and virulence, DNA repair and genome evolution. (33)

aging and longevity, becoming a centenarian Dr. Bonnie Bassler - Princeton, (30) has shown that cellular and prokaryotic life has had 3 billion years to construct these communications for beneficial and defensive pathways. Odd that this was not obvious, as this planet is a gigantic "Chemical Soup" ... and humans are just a new/recent - collective of organisms.

Bonnie is "The Bacteria Whisperer", The Secret, Social Lives of Bacteria | Dr. Bonnie Bassler. june/2015 Quorum sensing is wide-spread in the bacterial world, so understanding this process is fundamental to all of microbiology, including industrial and clinical microbiology, and ultimately to understanding the development of higher organisms.

Quorum sensing and new science for medicines and antibiotics
Zeiss: Scanning electron microscope image of Staphylococcus Aureus bacteria cells forming networks.

| Open image in new window |

Bacteria commonly exist in high cell density populations, making them prone to viral predation and horizontal gene transfer (HGT) through transformation and conjugation. To combat these invaders, bacteria possess an arsenal of defenses, such as CRISPR-Cas adaptive immunity. Many bacterial populations coordinate their behavior as cell density increases, using quorum sensing (QS) signaling. (34)

, are proving that life is based on some fundamental properties of simple molecules when collected together. The discovery in the 1960s that RNA could fold like a protein, albeit not into such complex structures, suggested an answer. No one had shown that RNA could catalyse reactions like protein enzymes. It was not until 1982, after decades of searching, that an RNA enzyme was finally discovered.

This was a huge boost to the idea that the first life consisted of RNA molecules that catalysed the production of more RNA molecules - “the RNA world”, as Harvard chemist Walter Gilbert dubbed it 25 years ago [Nature, vol 319, p 618].

Early life is based on functional groups of proteins. Proteins use cofactors to extend even further the range of reactions they can control. Without cofactors, life as we know it couldn’t exist. And it turns out that RNA enzymes can use cofactors too. Enzymes and Co-factors are what made humans. Billions of years later, some of the descendants of those first cells evolved into organisms intelligent enough to wonder what their very earliest ancestor was like. [First life: The search for the first replicator, by Michael Marshall - New Scientist].

 


 

 

Cancer Requirement for Growth | fermentable metabolites

In order to thrive and grow, cancer cells need fuel in the form of glucose, plus building materials in the form of protein, fatty acids, phosphate and acetate. These building materials are not readily available in your bloodstream, so cancer cells "steal" them from surrounding cells. The process that allows the cancer cells to invade surrounding tissue ... "is known as the Reverse Warburg Effect"". This effect is based on hydrogen peroxide generation caused by the interaction between oxygen free radicals and water.(2,3,4,10)

Like healthy cells, cancer cells cannot live without oxygen and nutrients. So they send out signals, called angiogenic factors that encourage new blood vessels to grow into the tumor. This is called angiogenesis. So invasive or metastasizing cancer, in essence, is the result of the Warburg Effect and the Reverse Warburg Effect.

Glucose Metabolism is one of the primary considerations within our mitochondria, a theory initially brought forth by Dr. Otto Warburg - (Video) in the 1920s. (wikipedia) Warburg show that Cancer Cells can only metabolize Glucose Sugar, they do not have the machinery to metabolize Fats for energy. Warburg's findings tell us that sugar "feeds" cancer while fats "starve" it.

This is ancient single cell metabolism whereby cancer cells revert to the cell's primordial energy and communication systems. So, it is possible to Starve cancer. Or in the case of the SAD - Diet we are on, we are instead Feeding It.

    Longevity and sugar Dr. Gary Fettke "Nutrition and Cancer - Time to Rethink", recommends reducing our amount of net daily carbs, particularly Fructose ...

  • Limit or eliminate sugar and net carbohydrates (non-fiber carbs) to avoid feeding cancer cells ...
  • Limit or eliminate PUFA oils and trans fats to prevent the formation of harmful free radicals and damaging small, dense LDL particles, we want to raise HDL levels ...
  • Limit protein (I recommend using a formula of one-half gram of protein per pound of lean body mass) to avoid stimulating mTOR pathway ...
  • Increase antioxidant intake (via whole food and/or supplements) to counteract free radical damage ...
  • Increase healthy fat intake to feed healthy cells while starving cancer cells ...
aging and longevity, becoming a centenarian

| Open diagram in new window |

 

The Importance of Diet for Successful Cancer Treatment

that cancer is not a genetic, but a metabolic disease, we can change our fundamental strategy and address our diet. Diet alone will not solve the cancer riddle. It will likely prevent it. Hippocrates, on Balance and Harmony, and Ames - Triage Theory on Reallocation - Scarce Resources; also, the Chinese Yin and Yang Theory.

When you look at all the science behind cancer, it brings to mind, body, spirit, lifestyle, the immune system, diet and detoxification ...

The foundational aspect that must be addressed is Metabolic Dysfunction and metabolic mitochondrial defects. This involves radically reducing the non-fiber carbohydrates in your diet and increasing high-quality fats. This does not mean a zero carbohydrate diet as most above ground vegetables have carbohydrates. We are avoiding below ground veggies. You need to have plenty of fresh, organic and fiber-filled vegetables (low net carbs). Ref: ... this site Carbohydrates and Longevity | contributor october/2016.

aging and longevity, becoming a centenarian As a follow up to this thinking, Dr. Fuhrman - The Healthiest, Anti-Cancer Foods: G-BOMBS has turned the food pyramid upside down, placing vegetables on the bottom as the pillar of support for the whole eating regiment. (7,8)

Dr. Seyfried proposes the Glucose/Ketone Index Calculator as a simple tool to help manage cancer. Glucose (mmol)/Ketone (mmol) = GKI. Therapeutic efficacy is considered best with index values approaching 1.0 or less. (10c)

Clucose (mmol)/Ketone (mmol) = GKI

Use Dr. Seyfried reference - (10c), on how to convert the information you get on a normal test report. Glucose (mg/dL) and Ketone (mg/dL). These values from mg/dL, milligrams per deci-liter, to millimolar (mM). Normalizing to a equivalent molecular weight is important. The molecular weights used for calculations in the GKIC are 180.16 g/mol for glucose and 104.1 g/mol for β-OHB, which is the major circulating ketone body measured in most commercial testing kits. The unit converter allows for compatibility for a variety of glucose and ketone testing monitors.

variety is a really important biological principle, and needs to be integrated it into a nutritional ketosis protocol. In fact, people should not be in nutritional ketosis long-term. You do have to integrate variety, so a day or two per week you might have a fair amount of carbohydrates, say 80 to even 120 (beans or grains added) grams of net carbs instead of the recommended 20 to 60 grams. This in no way implies ... eating Refined Carbohydrates is OK - It is Not. We get plenty of natural Carbohydrates from the Vegetables we eat. Ref's: Carbohydrates and Longevity | contributor october/2016, and Carbohydrate Intolerance - What does this mean? | contributor february/2017.

 


 

 

General Nutrition Guidelines |

Mitochondrial Biogenesis and Cancer Prevention

Dr. Mercola interviews Dr. Rhonda Patrick - Maximum Nutrition | April/2016. For optimal health, we need sufficient amounts of fats and proteins, carbohydrates are considered optional as there is no known Carbohydrate deficiency disease. However, ever since the advent of processed foods and industrial farming, it's become increasingly important to do your own research.

aging and longevity, becoming a centenarian Mitochondrial Biogenesis can be defined as the growth and division of pre-existing mitochondria. Mitochondria are direct descendants of an α-protobacteria endosymbiont that became established in a host cell. Owing to their bacterial origin, mitochondria have their own genome and can auto-replicate. Mitochondrial proteins are encoded by the nuclear and the mitochondrial genomes, i.e. mtDNA (mitochondrial DNA). (9,9a)

Mitochondrial Biogenesis is stimulated by the body's response to the environment, such as Stress, i.e. Exercise is Stress, This is good stress.. Exercise as stress, has shown to assist in telomerease activity. (9b)

Cancer growth and progression can be managed following a whole-body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. This transition will reduce tumor vascularity and inflammation while enhancing tumor cell death. (10,10a)

Metabolic therapies that induce a state of mild ketosis from caloric restriction or the ketogenic diet offer neuroprotection against a wide range of pathologies, and continues to be an emerging strategy for the metabolic management of cancer. Metabolic Therapies: Therapeutic Implications and Practical Application | Dr. Dominic D'Agostino | october/2014. (14), and a more current discussion with Dominic and Dr. Rhonda Patrick Modified Atkins Diet, Keto-Adaptation, Ketosis & More | Dr.'s D'Agostino and Patrick | April/2016.

aging and longevity, becoming a centenarian

| Open diagram in new window |

Dr. Sanja Goupta - The Gupta Guide (Note: this critism of our health care system has since conveniently disappeared) showed how lacking the medical professionals were in their knowledge of a basic dietary guide for cancer. Less than 1 in 5 NCCN institutions had any guide lines at all, yet cancer metabolism has been known since the 1930's ... Warburg Effect.

A key part of the Hippocratic Oath has been forgotten ...
“I will prevent disease whenever I can, for prevention is preferable to cure ...“
The common phrase you hear from doctors today is ... I will do no harm ..., but we ask - isn't ignorance, which leads to the wrong diagnosis the same as Harm, especially when it comes to human life?

Big-Pharma does not allow for Prevention, it propagates medicine by chemistry i.e. pharmaceuticals, which we now know as a Failed Experiment. The fact that the Pharmaceutical Industry got their medicinal clues and subsequent compounds from the environment, is lost. All pharmaceuticals are bases on nature's organic compounds. There are great scientists working on the health and wellbeing of people, but they try to Override instead of Support metabolic processes.

Ketogenic diets (KD or LCHF) may act as a co-adjuvant cancer therapy by two different mechanisms that both increase the oxidative stress inside cancer cells. Lipid metabolism limits the availability of glucose for glycolysis. Ketogenic diets are composed of high fat, moderate protein and low carbohydrates, which favor mitochondrial respiration (oxidative phosphorlation) rather than glycolysis for energy metabolism. Lipid metabolism forces cells to derive their energy from mitochondrial metabolism leading to ROS production. Cancer cells will be predicted to selectively experience oxidative stress. (14a,14b,14c)

Emerging data suggest a possible therapeutic utilization of ketogenic diets in multiple neurological disorders apart from epilepsy, (14d,14e) including head ache, neurotrauma, Alzheimer's and Parkinson's disease, sleep disorders, brain cancer, autism and multiple sclerosis. (14f)

The ketogenic diet (LCHF-KD) is now a proven therapy for drug-resistant epilepsy and used actively for 22 years by The Charlie Foundation for Ketogenic Therapies. A major supporter ... Meryl Streep introduces the ketogenic diets | April/2008 on the success of KD at John Hopkins Nutrition Clinic.

 

Translating Ideal Protein Requirements into Foods

DNA and cancer prevention Calculate the amount of daily protein you've consumed from all sources. Again, you're aiming for one-half gram of protein per pound of lean body mass. The Lean Body Mass (LBM - Calculator) is a part of the body. It is normally defined to be the body weight minus the body fat. Typically lean body mass is 60-90% of the total body mass. If you're currently averaging a lot more, think more like the Asian culture does. The body recycles 70 grams per day; therefore, the average person only needs about 80 grams ... Ref: Proteins - How Much.

Animal proteins are an accoutrement not the main course. This is reflected by ... the Centenarian Diet which is espoused on this site. (Ex. LBM = 160lb ~> 80g, which is about 12 - 14g per snack/meal, 6 portions.) Too much protein puts a burden on your kidneys as they are acids, also, your liver can convert proteins to Glucose.

 

Beware of Unhealthy Fats

DNA and cancer prevention

When it comes to fat, it's really crucial to distinguish healthy from the unhealthy ones. The vast majority of fats people eat are actually very unhealthy. As a general rule, avoid all processed and bottled vegetable oils, which are typically high in damaged omega-6 fats.

This Site: Fat and Oil in modern diets, where did the Omega 3's go ... D. S. McGerk | contributor, may/16 Prior the WWI and WWII our farm animals were just as healthy as salmon ... What Happened?

Anthropological evidence also suggests that the ratio human beings evolved eating is somewhere around 1:1, while the ratio today is about 16:1. According to Dr. Stephan Guyenet who has done a lot of research on non-industrial populations, typical Omega-6:Omega-3 ratios for non-industrial populations ranged from 4:1 to 1:4.

 


 

Nutritional Ketosis Can Offer Hope and Health

Nutritional Ketosis is when our metabolism runs off of energy that comes from our reserved fat instead of glucose. We are just beginning to understand the biological intricacies of aging. A growing body of research is challenging the belief that aging is beyond your control, prompting scientific research ... In a report published in the August 2013 issue of Cell Reports, (6) scientists discovered that the "mTOR gene" is a significant regulator of the aging process ..." (5).

Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Cancer: A Metabolic Disease with Metabolic Solutions | Dr. Thomas Seyfried | march/2015. (10a,b) .

Calorie restriction diets have been around and the results have been increased longevity. Our Circadian Rhythm controls all gene expression and organs, (some have their own clock) and Time-Restricted Feeding (TRF) | contributor, august.2016 is important to the body's repair/rebuild metabolic pathways. (11) Ex: proteins can misfold and aggregate, these structures must be removed, or else they can confer cytotoxicity. i.e. (Alzheimer's disease - AD) (11a)

The CR Society has stricter views on Calorie Restriction, CR Society International! but this is not the real story as the timing of gene expression is far more important. Hippocrates used Fasting as a cure. This is the reason Coconut Oil "MCTs" has gained popularity and Medium Chain Triglycerides have been proven successful in Ketogenic Diets. Dr. Mercola Interviews Dr. Perlmutter - Ketogenic Diet | Dr. Perlmutter author "Grain Brain" | april/2014. (12).

 

The role of Cooking in Nutrition | Catch 22

Cooking food does destroy many of the enzymes in a food needed to digest that food. This is because enzymes are proteins and they become denatured. (Note 2) Cooking food does change to the value of the food in many different ways, and some foods release their nutrients more readily when cooked. A key element is the natural enzymes thay come along with the vegetables.

Enzymes are catalysts which speed up and facilitate reactions in our body. In fact, some biochemical reactions will not even occur without these enzymes. It is beneficial to eat some of our vegetables in the raw state and Dr. Mercola ... (Mercola eats - 85% raw) and from our contributors ... Raw vs. Cooked Vegetables | contributor May/2016 evaluates our requirements for raw food enzymes. See also: Snacks, Salads, and Smoothies (3 S's).

However, we now know we are feeding 2 organisms and the gut microbiota needs its share, particularly fiber. Cooking foods Soft Food Diet, produces a net gain in available energy which our large brain and small intestines benefit from. Dr. Richard Wrangham and his team and other researchers, have shown that the Soft Food Diet, has benefited human evolution and still benefits us today. Catching Fire: How Cooking Made Us Human | Dr. Richard Wrangham | february/2013. (40)

 


Ok - Now What?

Anti Aging Nutrition for any Age

are the primary effort of every living animal on this planet. Even plants must seek nutrition and fertile soils with a living microbiome - soil health, to thrive. Humans are no different, as we sometimes forget why we eat. We carry our own microbiome - guts and are seeking Energy for survival, and Nutrition for growth and disease control. Supplying the body with proper nutrition is our reason for eating. ... D. S. McGerk - Why do we Eat | contributor april/2016. What's Cooking?: The Meat and Potatoes of Human Evolution ... Dr. Jeanne Sept | july/2013. Catching Fire: How Cooking Made Us Human ... Dr. Richard Wrangham | february/2013. The rise of Omega 6 fats, and where did the Omega 3's go from our food sources ... D. S. McGerk - Fat and Oil in modern diets | contributor may/2016

Dr. Warburg (Wiki) discovered that in the presence of oxygen, cancer cells overproduce lactic acid, and this became known as the Warburg Effect. The Metabolism of Tumors in the Body, Warburg O, Wind F, Negelein E. 1927 (PubMed) (.pdf) So what does this tell us about the nutritional origins of cancer? Warburg's findings tell us that sugar "feeds" cancer while fats "starve" it. Healthy cells can use either glucose or ketone bodies from fat as an energy source, but cancer is metabolically restricted to using glucose only. Cancer cells must ferment, so Dr. Gary Fettke cured his own cancer using a Ketogenic diet as a cure. 'A 'Nutritional' model of Inflammation & Modern Disease' | Dr. Gary Fettke | october/2014. (4)

Our modern society created a Nutritional Disease; therefore, we need a Nutritional Solution. But, doctors are not trained in nutrition, medicine as we know it is in trouble, can we be better doctors than the AMA provides. We certainly can acquire the knowledge to ask better questions. The AMA has failed in their mission. Dr. Noakes gives a good talk on the problem ... The Great Diet Controversy: UCT - Challenge Beliefs Dr. Tim Noakes | november/2013 (12) and Dr. Mercola & Dr. Greger on How Not To Die December/2015. (13) Dr. Mercola and Dr. Chutkan talk on Food as Medicine - The Baby Connection and the importance of Gut Health ... referred to as Complimentary or Alternative medicine ... Dr. Mercola and Dr. Chutkan on Gut Health | February/2017. (14) Dr. Chutkan has a 77% success rate of taking her patients Off Medications.

is where we stand. OMG - We can not get to the future Sick; therefore, if we apply the Dr. Ames' - Triage Theory and aim high ...

The following actions must be considered:

Simple solution, avoid carbohydrates as they offer no known nutritional benefits. Carbohydrates are however packaged in food source organisms that do provide Longevity Vitamins, Our foods provide Phytonutrients, macronutrients, micronutrients (for critical DNA repair) (R1), Polyphenols, Phytosterols, Flavonoids, Lignans, Antioxidants, and Carotenoids, that do allow life to continue. Ref: 100 richest dietary sources of polyphenols. (Resource 1,2,3)

Certainly avoid processed carbohydrates, fats and oils, and packaged processed foods. A direct result of too many carbohydrates is Insulin Resistance functional manifested as Carbohydrate Intolerance. Dr. Volek discusses his current views on the benefits of a LCHF plan - Health-Promoting Effects of a Low-Carbohydrate Lifestyle | july/2016 and this site follows this type of plan with the addition of Dr. Ames' "Triage Theory" ... the Centenarian Diet.

What path are You On?

 


Notes:

  1. Biographical Sketch: Otto Heinrich Warburg, PhD, MD, by Richard A. Brand, MD This biographical sketch of Otto Heinrich Warburg corresponds to the historic text, The Classic: The Chemical Constitution of Respiration Ferment (1928), available at DOI 10.1007/s11999-010-1534-y.
  2. Mitochondria's Role in Cancer: When cancer cells are present, the reactive oxygen species produced as a byproduct of ATP production normally send a signal that sets in motion a process of cellular suicide, also known as apoptosis. Since you generate cancer cells every day, this is a good thing. By killing off damaged cells, your body can eliminate and replace them with healthy cells. Cancer cells, however, are resistant to this suicide protocol, and have a built-in defense against it as articulately explained by Dr. Warburg and subsequently by Thomas Seyfried - "Cancer as a Metabolic Disease", Thomas N Seyfried, Laura M Shelton, Nutrition & Metabolism 2010, who has done extensive research on cancer as a metabolic. The finding indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. (40,40a)

    We are all hoping that We can Starve Cancer by reducing the availability of glucose, even though our bodies can produce all the glcose it needs. The Question is - if we eliminate refinned sugars and carbohydrates ... will this starve cancers? If nothing else, it certainly will improve out Epigenetic Legacy. Ref: Intergenerational Transmission of Epigenetics | contributor Feb/2017 and Exponential Growth of Epigenetic Affects contributor march/2017.

    have six acquired alterations described as the hallmarks of nearly all cancers and included, 1) self-sufficiency in growth signals, 2) insensitivity to growth inhibitory (antigrowth) signals, 3) evasion of programmed cell death (apoptosis), 4) limitless replicative potential, 5) sustained vascularity (angiogenesis), and 6) tissue invasion and metastasis. (40a, Hanahan D., Weinberg RA)

    OMG - these little bastards can "Evade" apoptosis - ? These 6 hallmarks indicate how difficult this problem has been for our Medical and Scientific communities. Maintaining a steady state metabolism and healthy immune system is the responsibility of the User. Mercola - Take control of your Health.
  3. Cooking denatures the proteins in food, this process is similar to what the acids do in the stomach. Both processes disrupts the normal alpha-helix and beta sheets in a protein and uncoils it into a random shape. Ileal studies have shown that cooking denatures proteins and makes them more bioavailable.. (41,42) Researchers have shown that digestibility goes from 51 % to 90 % when cooked vs raw. The energetic benefit of cooking increases bioavailability by approximately 78%.. (43) PowerPoint slides. (44)

 


living to 100
VA Pittsburgh Healthcare System
Curbing Cancer's Sweet Tooth

Dr. Tan is introducing Veterans with advanced cancer to a ketogenic LCHF - (high-fat, adequate-protein, low-carbohydrate) diet. This eating plan starves cancer cells while still meeting a patient's nutritional needs.

Take Action
Enhancing hero-worthy care for
Our Nation's Veterans.

[ + ] Sources and References:

  1. Video youTube, Bonnie is "the Bacteria Whisperer", The Secret, Social Lives of Bacteria | Dr. Bonnie Bassler. june/2015.
  2. DNA Repair PUBMED, NCBI, PUBMED, Effects of micronutrients on DNA repair. Collins AR, Azqueta A, Langie SA.
  3. DNA Repair, NutritionFacts.org, Which Fruits and Vegetables Boost DNA Repair?
  4. A Best Answers for Cancer - Organization, Best Answer for Cancer Foundation (BAFC).
  5. B New York Times, April 2009, Forty Years’ War: Advances Elusive in the Drive to Cure Cancer, by Gina Kolata.
  6. C Dr. Mercola.com, 2017, The Healing Platform: Build Your Own Cure for Cancer.
  7. 1 U.S. National Library of Medicine, Genetics Home Reference, mDNA, mitochrondrial DNA, Guide to understanding genetic conditions.
  8. 1a NCBI, Molecular Biology of the Cell. 4th edition. How Cells Obtain Energy from Food
  9. 1b AJHG, Cell.com Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell, Simon Wisnovsky, Eric K. Lei, Sae Rin Jean, Shana O. Kelley.
  10. 1c ScienceDirect, V1823:12, 201, Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner, Magdalena Franka, et al.
  11. 1d Dr. Mercola.com, How Your Mitochondria Influence Your Health, January 24, 2016
  12. 2 Travis Christofferson, "Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure." The Metabolic Theory of Cancer and the Key to Cancer Prevention and Recovery
  13. 3 Mercola.com - How Nutrition Influences Cancer, Is it possible that chromosomal damage is simply a marker for cancer and not the actual cause of the disease?
  14. 3a Cell. 2000, 100: 57-70. 10.1016/S0092-8674(00)81683-9. Hanahan D, Weinberg RA: The hallmarks of cancer.
  15. 3b Cell 2011, Volume 144, Issue 5, p646–674, 4 March 2011 Hallmarks of Cancer: The Next Generation, Douglas Hanahan, Robert A. Weinberg
  16. 4 youTube Dr. Gary Fettke - A Nutritional model of Inflammation & Modern Disease.
  17. 4a NCBI PubMed, doi: 10.1016/j.nut.2012.05.001. Epub 2012 Jul 26. Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Fine EJ, et al.
  18. 5 The Aging of Mice and Men, By Dr. Mercola, Ketogenic Diet Improves Insulin Sensitivity and Numerous Aging Markers
  19. 6 Cell.com, Cell Report - Volume 4, Issue 5, p913-920, 12 September 2013, Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression, Slowing of Aging after Genetic Reduction of mTOR Expression,J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, Nisha Narayan, Marie M. Fergusson, Ilsa I. Rovira, Michele Allen, Danielle A. Springer, Cory U. Lago, Shuling Zhang, Wendy DuBois, Theresa Ward, Rafael deCabo, Oksana Gavrilova, Beverly Mock, Toren Finkel
  20. 7 Dr. Fuhrman, Smart Nutrition, Superior Health ™ , The Healthiest, Anti-Cancer Foods: G-BOMBS
  21. 8 Dr. Fuhrman's Food Pyramid vs. USDA Pyramid Dr. Fuhrman's Nutritarian food pyramid is based on the principles of high nutrient eating
  22. 9 NCBI PMC doi: 10.1042/bse0470069, Regulation of mitochondrial biogenesis, François R. Jornayvaz and Gerald I. Shulman.
  23. 9a Frintiers in Physiology, march 2015, Can endurance exercise preconditioning prevention disuse muscle atrophy? Michael P. Wiggs
  24. 9b youTube, Stess and Mitochondrial biogenesis - Dr. Mercola Interviews Rhonda Patrick apr/2016
  25. 10 Travis Christofferson, author of the phenomenal book, "Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure."
  26. 10a Nutrition and Metabolism 2010 7:7 DOI: 10.1186/1743-7075-7-7 Cancer as a metabolic disease, Thomas N Seyfried, Laura M Shelton
  27. 10b youTube, Cancer: A Metabolic Disease With Metabolic Solutions, Dr. Thomas Seyfried. mar/15
  28. 10c Nutrition & Metabolism, 2015 12:12 DOI: 10.1186/s12986-015-0009-2 The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer, Joshua J Meidenbauer, Purna Mukherjee and Thomas N Seyfried.
  29. 11 NCBI PMC, Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies, Aaron Ciechanover and Yong Tae Kwon.
  30. 12 youTube, Dr. Mercola Interviews Dr. Perlmutter - Author, Grain Brain, apr/2014
  31. 13 youTube, Catching Fire: How Cooking Made Us Human | Dr. Richard Wrangham | february/2013.
  32. 14 youTube, Metabolic Therapies: Therapeutic Implications and Practical Application, Dr. Dominic D'Agostino | october/2014.
  33. 14a NCBI PMC, Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Bryan G. Allen, et.al.
  34. 14b NCBI PubMed, Ketogenic diets: from cancer to mitochondrial diseases and beyond. Branco AF, et.al.
  35. 14c MCBI PMC 2013, Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets, A Paoli, A Rubini, J S Volek, and K A Grimaldi.
  36. 14d Authority Nutrition by Rudy Mawer, Can a Ketogenic Diet Help Fight Cancer?
  37. 14e NCBI PubMed 2008 Nov;10(6):410-9. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Barañano KW, Hartman AL.
  38. 14f NCBI PMC doi:10.3389/fphar.2012.00059 The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders, Carl E. Stafstrom and Jong M. Rho.
  39. 15 youTube, Diet, exercise, and lifestyle optimization for cancer treatment and prevention, Dr. Colin Champ, june/2016.
  40. 15a PubMed, Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. Champ CE, et al.
  41. 15b PubMed, Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation. Klement RJ, Champ CE.
  42. 16 youTube, Dr. Colin Champ - Augmenting Cancer Therapy with Diet
  43. 17 Caveman Diet, The Caveman Diet by the Caveman Doctor - Dr. Champ.
  44. 18 SpringerLink - Cance and Metastasis Reviews, 2014,V33:1 pp 217-229, Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation, Rainer J. Klement, Colin E. Champ.
  45. 19 youTube, Prof. Tim Noakes - 'Medical aspects of the low carbohydrate lifestyle, sep/2014
  46. 20 youTube, 2016 Health-Promoting Effects of a Low-Carbohydrate Lifestyle, Dr. Volek
  47. 20a Art and Science of Low Carb - LCHF Web Site - Jeff S. Volek, PhD, RD & Stephen D. Phinney, MD, PhD.
  48. 30 Princeton - Molecular Biology Labs, Welcome to the Bassler Lab
  49. 31 NCBI PubMed, Local and global consequences of flow on bacterial quorum sensing. Kim MK, Ingremeau F, Zhao A, Bassler BL, Stone HA.
  50. 31a American Society for Microbiology, Communication among Oral Bacteria, Paul E. Kolenbrander, et.al.
  51. 32 AgingSciences - Anti-Aging Firewalls, Quorum Sensing Part 2 - Intra and inter-species molecular communications, July 2013 by Vince Giuliano
  52. 32b AgingSciences - Anti-Aging Firewalls, Quorum sensing Part 1: quorum sensing inhibition via phytochemicals - a new approach against infectious diseases. July 2013 by Vince Giuliano
  53. 33 Nature Reviews Microbiology 12, 317–326 (2014) doi:10.1038/nrmicro3241, CRISPR–Cas systems: beyond adaptive immunity, Edze R. Westra, Angus Buckling & Peter C. Fineran
  54. 33a CELL - Molecular Cell, Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems, Adrian G. Patterson, Simon A. Jackson, Corinda Taylor, Gary B. Evans, George P.C. Salmond, Rita Przybilski, Raymond H.J. Staals, Peter C. Fineran
  55. 40 BioMed Central - Nutrition & Metabolism review, Cancer as a metabolic disease, Thomas N Seyfried and Laura M Shelton
  56. 40a Cell. 2000, 100: 57-70. 10.1016/S0092-8674(00)81683-9. Hanahan D, Weinberg RA: The hallmarks of cancer.
  57. 41 youTube, University of California Television, CARTA: The Evolution of Human Nutrition
  58. 42 youTube, Humans: The Cooking Ape, a lecture by Richard Wrangham
  59. 43 JN, The Journal of Nutrition, 1998, Digestibility of Cooked and Raw Egg Protein in Humans as Assessed by Stable Isotope Techniques, Pieter Evenepoel, Benny Geypens, Anja Luypaerts, Martin Hiele, Yvo Ghoos4, and Paul Rutgeerts
  60. 44 JN, The Journal of Nutrition, 1998, Digestibility of Cooked and Raw Egg Protein in Humans as Assessed by Stable Isotope Techniques, PowerPoint Slides.

About Us

is a positive online community for seniors who are interested in longevity and becoming centenarians. Living to 100 years of age becomes a goal, and sharing and exploring this goal is an issue that matters to those in the golden years. A platform for the energetic, creative, and productive, to share life experiences by contributing your experiences on this site. Founded to explore quality living, healthy and anti aging, longevity and Becoming Centenarians.