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Risky - Nutrition

  Supplements, Vitamins, and Living past 100 years

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Risky - Supplements and Nutrition

Biochemistry of vitamins and longevity for centenarians

(1) was a long time radio talk show host in the San Francisco Bay Area. A caller once called in and asked Dr. Edell ... Do you take Supplements? and his answer was a clarification to his listeners in its simplicity ... No, I eat food.

From the back cover of "Eat, Drink & Be Merry, Dean Edell, M.D."

"... As one of the first media doctors, Dr. Edell knows better than anyone the dangers of distorted medical reporting. With colorful detail, he shows how medical consumers are made neurotic at a time when people are healthier than ever before. Dr. Edell sorts through the morass of research, distinguishing documentable fact from panic-inducing fiction. With trademark humor, grace, and style, he shares with us the essential reassuring facts about our health: you can be fatter than you think; too much exercise might kill you; and yes, sex will add years to your life!"

  • People who crave ice chips may have a nutritional deficiency?
  • Saturated fat may reduce the risk of stroke?
  • Dementia appears to be less common among those who eat more fish?
  • You can lose weight by fidgeting, chewing on a pencil, or drinking coffee?
  • Sex can cure headaches?
  • Playing an instrument is not only good for your mental health, it burns 160 calories an hour?

 

Supplements ... | Or, just eat real food

show that antioxidants have no real effect as a supplement, whereas real foods have a balanced environment for micronutrients. The positive is that Abram Hoffer, MD, PhD, always said: "No one dies from vitamins." He was right when he said it and he is still right today. Orthomolecular.org -No Deaths from Vitamins. Absolutely None. (1a) And this is a far cry from the estimated 1,000,000 patients that die from medical errors (250,000 - 3rd leading cause), (1b) bad diagnostics and pharmacological reactions, and bad diet (the SAD - a US.gov recommendation). (1c)

The University of California Television (UCTV) has many leading researcher with data and opinions. Vitamins and Supplements: An Evidence-Based Approach | Dr. Jeffry Tice, october/2013 is one, and Dr. Tice gives some current findings, as an MD.

But the Good/Bad news is ... "Pharmaceutical Drugs are 62,000 Times More Likely to Kill You than Supplements according to the Alliance for Natural Health International (ANH-Intl). i.e. "Natural products Safe - Drugs as Dangerous as War". (11a,11b)

are finding evidence why Antioxidants Supplements might not be effective. Dr. Rhonda Patrick (Scientist) and other are discovering that when the body is Stressed (stress can be exercise, cold, heat, injury ... etc.) it turns on genes that produce an inflammatory response that produce the body's own antioxidants response. The body's anti-oxidants and immune response are far More Powerful than any Supplement. This is an inflammatory response and is desired as it builds muscle, repairs DNA damage, removes dead or quiescent cells.

Essentially, the body knows how to cleans up after stressful situations. The antioxidant response of the body is far more powerful than any supplement that can be taken. Dr Rhonda Patrick on Inflammation, Modafinil & Sensory Deprivation, and feeding your gut | september/2015 Supplementing, can interfere with the body's response, and this is what current researchers are finding. Dr. Dean Edell, is being proven to be right.

of your diet, and if you do that right, you can minimize the need to supplement.

Real foods provide bio-chemistry out bodies can understant, this is critical for living to 100.

 

Fish Oils ...

can be made for Fish Oil supplements. With modern farming practices, Omega-3's have disappeared from our diets (2,3,4). This is detrimental to brain and eye development and there is not enough fish in the ocean to meet the omega 3 needs of humans. Krill is the third largest animal bio-mass on the planet next to cows and humans.

However, since we killed off all the whales (95% est.) the krill can be harvested for human use. Salmon only turn red after they have swum out to the ocean and started eating krill. This is same of the "Pink Flamingo", as it turns pink when it starts eating kril and phytoplankton. Our body does convert LA (18:2n-6) (a plant based omega-6) and ALA (18:3n-3) (a plant based omega-3) to EPA (20:5n-3) and DHA (22:6n-3) but it is very inefficient, (5,6) and direct sourcing (eating fish) and supplementation of these omega 3's may be necessary.

"... The use of ALA labeled with radioisotopes suggested that with a background diet high in saturated fat conversion to long-chain metabolites is approximately 6% for EPA and 3.8% for DHA. With a diet rich in n-6 PUFA, conversion is reduced by 40 to 50%. It is thus reasonable to observe an n-6/n-3 PUFA ratio not exceeding 4-6. Restricted conversion to DHA may be critical since evidence has been increasing that this long-chain metabolite has an autonomous function, e.g. in the brain, retina and spermatozoa where it is the most prominent fatty acid. In neonates deficiency is associated with visual impairment, abnormalities in the electroretinogram and delayed cognitive development. ..." (6,7,8)

 

Fat Soluble Vitamins | Discovered 1917 - 1929

Fat soluble vitamins (A's, D's, E's, K's) are components of the pathway that regulates protein synthesis. This of course involves enzymes and hormones. It is not a simple task to supplement these vitamins. They occur in many chemical forms derivatives and all forms have functions within human metabolism.

Vitamin A | Fat Soluble Vitamin Complex

... vitamin A is a group of compounds (e.g., retinol, retinoids, carotenoids, vitamin A1, A2, etc.). These compounds work synergistically with one another in addition to working as cofactors with other nutrients and substances (e.g. iron, bile, etc.). Synthetic vitamin A is a fractionated supplement and is not part of the original food complex, and the chances of toxicity and side effects become possible. (9) Biochemistry of vitamins and longevity for centenarians

Are vitamins a food - those who take vitamin A (A palmitate or even beta carotene, but over 500 carotenoids in nature) are taking a synthetic isolated vitamin and failing to ingest the rest of the complex needed to perform our body's biochemical tasks. Therefore, vitamin A is not an isolated substance, but rather a group of compounds. (10)

Vitamin A compounds are fat soluble (from animals - retinoic acid, retinal, and retinol and from vegetables - carotenoids, "provitamin A - vitamin A precursors") and can be stored in the liver for long periods of time; therefore, it has a high potential for toxicity. The first sign of vitamin A overdose us usually headaches, followed by chapped lips, dry skin, fatigue, emotional instability and bone and joint pain. (11) Google for complete side effects and dosage.

    Vitamin A, actually refers to several different but related nutrients that can be divided up into two main categories: (10a,10b)

  1. Retinoids (aka retinol, retinal, retinoic acid, retinyl esters), the bioavailable forms of vitamin A found in animal foods. (the fat-soluble, biologically active vitamin A found in animal foods)
  2. Carotenoids, (Carotenes and Xanthophylls) previtamin A found in plant foods. (the water-soluble pro-vitamins found in plant foods)
  3. Biochemistry of vitamins and longevity for centenarians Retinoids vs. Carotenoids - Animal sources of retinol is bio-available, which means the body can utilize it. The vitamin A from plant sources, in contrast, must first be converted to retinol to be useful in the body. To put this in perspective, that means one must eat 4 1/2 pounds of carrots to potentially get the amount of useable A as in 3 oz. of beef liver.

    Chris Kresser - aka The Healthy Skeptic explains why you can’t get vitamin A from eating vegetables on his site The Healthy Baby Code. There’s a common misconception that beta-carotene found in fruits and vegetables is the same thing as vitamin A. It’s not. Chris says ... vegetables like carrots and red peppers are not adequate food sources of vitamin A. Vitamin A is found in significant amounts only in animal products like liver and grass-fed dairy. (10c,10d)

    Where did the Omega 3's go, and Why is Butter yellow? | contributor April/2016 references the fact that Butter is yellow because of Vitamin A.

Vitamin A deficiencies have been linked to many functions in the human organism. Growth and repair of bones, teeth, collagen, cartilage, enhances many immune functions, and most critical cell differentiation. Cell differentiation is part of the Stem Cell World, and is the process whereby cells change to take on different structures and functions. Vitamin A has the ability to interact with a cell's DNA. (Vitamin D, acts in a similar capacity.)

we cannot make red blood cells without Vitamin A. Most know that Vitamin A is important in Eye Health, but our red blood cells are all made from Hematopoietic Stem Cell (HSC) activity known as Hematopoiesis. Without Vitamin A this stem cell activity is disrupted. These stem cells move in and out of dormancy on a diet sufficient in vitamin A, but are disrupted and stress the blood system and cause a malfunction is healthy blood cell replacement. [Triage Theory].

, and there's evidence suggesting that without vitamin D, vitamin A can be ineffective or even toxic. On the other hand, if you're deficient in vitamin A, vitamin D cannot function properly either, so a balance of these two vitamins is essential.

Unfortunately, many synergy pathways within the human body are not studied. Hence, we do not yet know the optimal ratios between these two vitamins. Moreover, both vitamin A and vitamin D production is tightly controlled in your body, and taking either of them in supplemental form ends up bypassing important controls that keep you from experiencing potential toxic effects. For these two reasons, it's best to get vitamins A and D from food and sun exposure, rather than relying on supplements.

is Pharmaceutical Drugs are 62,000 Times More Likely to Kill You than Supplements according to the Alliance for Natural Health International (ANH-Intl). (11a,11b) i.e. "Drugs are as Dangerous as War".

 

Vitamin B complex | Minimum requirements

Re-Think your B vitamins, your body has Requirements.

Vitamin B's seem to work as advertised. But here, the RDA/RDI might not be sufficient. B12 for example is directly involved in the Methylation Cycle (12,12a) and the uptake mechanism gets slower with age. Folic acid (conjugate base folate) is a B vitamin. It is also referred to as vitamin M, vitamin B9, folate or folacin, pteroyl-L-glutamic acid, and pteroyl-L-glutamate. Folic acid is a member of the vitamin B family that stimulates the hematopoietic system (blood-making organs).

Folates occur naturally in many foods and, among plants, are especially plentiful in dark green leafy vegetables. Dr. Group - 15 Foods High in Folic Acid Folate and B vitamin deficiencies are serious. Livestrong.com, Foods That Are High in B Vitamins | by MOLLY MCADAMS | january/2015 discusses general requirements and use, also Dr. Mercola has done extensive research and also sells trusted supplements at his site. Ref: B Vitamins May Reduce Brain Shrinkage by Up to 90 Percent | june/2013 .

Some Vitamin B's present a problem:

  1. Folate (Vitamin B9 or Vitamin B11) supplemented as Folic Acid is not good. It is not processed the same in your body and can interfere with our immune system and the functioning of B12. Naturally occurring 5-MTHF has important advantages over synthetic folic acid - it is well absorbed even when gastrointestinal pH is altered and its bioavailability is not affected by metabolic defects. (12b,12c) Methylated folates provide better assimilation and protection in neurological pathways and working with Vitamin D in the skin. (12d,12e) Supplemental (6S)-5-methyTHF is immediately available as folates play crucial roles during cell growth and division and prevention of NTD (Neural Tube Defects). ((12f) - Figure 1, this PDF paper has 143 references to scientific studies)
  2. Cobalamin (B12) supplemented as Methylcobalamin is the right form. The cheapest form found is "Cyanocobalamin" and should not be used. Cyano means Arsenic compound and we get more than enough arsenic in our water supplies, especially if you are on well water. Your body has to turn B12 into its methy form to be used in the methylation cycle. This requires dropping the arsenic before it can be re-methylated and used. Arsenic is a heavy metal and heavy metals interfere with the body, and act as carcinogens. Carcinogens are recognized as an environmental and occupational pollutant. Harvard School of Public Health confirmed the association between arsenic exposure and DNA methylation, a biological process that causes many debilitating and fatal diseases. (12g,12h)
  3. Although B vitamins are water soluble and don't stay long in your body, large doses of certain B vitamins can cause serious toxicity. Taking supplements needs your personnal touch when researching. We need to learn the symptoms of Vitamin Toxicity Mother Nature packs them in cellular tissues of plants and animals, hence, they naturally come with control mechanisms and well distributed within the organism's cells. This is an area where you "Doctor" should have the latest information, as the B Vitamins are important in fetal development.

Family of Vitamins - The B vitamin family is made up of eight B vitamins. Although they are commonly recognized as a group and often work together in the body, each of the B vitamins performs unique and important functions. These vitamins help the process your body uses to get or make energy from the food you eat. They also help form red blood cells. You can get B vitamins from proteins such as fish, poultry, meat, eggs, and dairy products. Leafy green vegetables, beans, and peas also have B vitamins.

B Vitamins are water soluble. This means they dissolve in water and are not stored by the body. Since they are eliminated in urine, our metabolism requires a continuous daily supply from our diet.

 

Vitamin C

... Ascorbic Acid in not vitamin C even though the FDA allow it to be called vitamin C. But, your body metabolized nature's vitamin C complex into L-Ascorbic Acid, or simply ascorbate (the anion of ascorbic acid), this is essentially the same as Sodium Ascorbate we get as a supplement. Do not use Calcium Ascorbate, buffering is not necessary. Most of our primate friends, cows and many other animals, can make their own vitamin C. (They make and use 10 times what the RDA/RDI is for humans ... ?)

Biochemistry of vitamins and longevity for centenarians Our primate ancestors lost the ability to make their own vitamin C about 60 million years ago. Those ancestors didn't need to make vitamin C, however, because they regularly ate fruit. (13,13a,13b) More recently, our hunter-gatherer ancestors got an abundant supply of vitamins from the game they killed and the plants they collected.

, people began to eat more vitamin-poor starches like wheat and corn. (14) And as we've transformed our diet even further, we've put ourselves at risk of vitamin-related diseases and triggering the Triage Theory of Nutrition. (15)

We still have the gene for making the enzyme that makes vitamin C, but for some reason it is not functional in humans, so we cannot make vitamin C and must get it from our diet - Greens and Fruits, (1 pepper = 300mg, are highest, a pepper is a fruit, i.e. seeds). Our cells use vitamin C, and when we are fighting diseases, our bodies use large amounts. There is a powerful family of over 6,000 antioxidants that have a symbiotic working relationship with vitamin C each increasing the other's effect. (16,16a)

From 1941 ... 2012, research that vitamin C supplementation has improved all bodily functions, Heart disease, Blood vessels/inflammation, Cholesterol metabolism, High blood pressure. High doses of vitamin C were shown to cure polio, hepatitis, cancer, ebola (hemi - blood, similar to scurvy), tuberculosis, before vaccines ... the body under stress consumes large quantities of vitamin C. Dr. Levy Ascorbate - Liposomal Vitamin C and Antioxidant Therapy | june/2014, , and from 2013, Vitamin C - Ascorbate - Liposomal Vitamin C and Antioxidant Therapy - Dr. Thomas E. Levy | Jun/2013. Note - support for the Triage Theory and root causes of malnutrition do to imbalances in nutrition.

Found in many fruits and vegetables and in some animal organs, vitamin C is a delicate nutrient that is destroyed by heat. Consequently, in the modern diet where the majority of most people's meals (62 %) consist of highly processed foods, little vitamin C remains for absorption. Lots of controversy still ... (17) A high quality excellent lecture by Dr. Suzanne Humphries follows, this lecture is to medical doctors and backed by science and human trials, Lecture on vitamin C | by Dr. Suzanne Humphries | february/2015

... vitamin C first before antibiotics, as antibiotics impair the immune system and kills friendly's and foe's. Vitamin C is metabolized when the body generates its own antioxidants and inflammation response, and is itself a powerful antioxidant ...
Dr. Saul, , Dr. Ames, , Dr. Levy, , Dr. Humphries, .

Conclusion: the animal kingdom uses 30mg/kg vitamin A per day in metabolic functions. We either make this (cows 4,500 mg/day) or have to eat what we require (30mg/kg/day). It is shown that animals when they get sick accelerate their need for vitamin C, and some animals do not get sick because they can make 10 times more Vitamin C in response to pathogens. More importantly glucose competes and effectively restricts vitamin C from entering cells. This means that the greater the content of circulating blood sugar the less vitamin C will enter the cell. (17a,17b,17c)

    Implications:

  1. → 30 X 70kg = 2100mg/da for 160lb person, and up to 5 times that when sick, plus of course avoiding Carbohydrates, particularly Sugars.
  2. → And yes it is proven that high doses of Vitamin C is safe - major study 2014, and yes they did cure Polio with vitamin C. (17d,dd,17e)
  3. → The number 1 source is the Pepper Fruit, not citrus fruits. ref ... this site Vegetables & Longevity.

 

Vitamin D | A Fat Soluble Vitamin

Really a pro-hormone: 1,25 dihydroxy-vitamin D

Biochemistry of vitamins and longevity for centenarians

Your parents and grandparents can probably remember Rickets and Osteomalacia, they are returning, along with birth defects due to Vitamin D deficiency. Rickets (children), Osteomalacia (adults) is a systematic disease with our skelton mostly involved, but the nervous system, muscular system, and other pathways may also be involved. Vitamin D deficiency causes low calcium and phosphate, which lead to secondary hyperparathyroidism.

    Symptoms Rickets:

  1. Generalized and Isolated bone pain.
  2. Muscle aches and pains.
  3. Leading to: Fibromyalgia, psoriasis, chronic fatique syndrome (which manifests like motor neuron disease), ALS, or being written off as depressed. (18,18a,18b)

There are over 34,000 scientific investigations to date on how vitamin D works in your body, yet it continues to be ignored by large segments of the population and even many physicians. Bone deformities are on the rise in children. No Sun ... no Vitamin D, you can get Vitamin D at the grocery store, but, the Skin is the largest organ in your body and does many things beside making Vitamin D when exposed to sun. The Vitamin D the body makes lasts 3 times longer. (Note 1,2)

it turns out that the skin draws energy from the sun as cholesterol-sulfate acts like solar panels. Vitamin D is manufactured out of cholesterol and the sulfated form is water soluble for easy transport throughout the body and to the liver. Cholesterol is vital to health as it is used in all cells and is an integral part of the cell wall. According to Dr. Stephanie Seneff a sulfur deficiency and consequently a cholesterol-sulfate deficiency in the skin leads to Bad Blood and Cardiovascular disease. Ref, contributor article - Human Animal - Are we part Plant | contributor February/2017

can be made for Vitamin D supplements as we no longer get enough sun (UVB specifically). The current estimate is that 50-70% of the population is Vitamin D deficiency. We In addition, Glass does not let the correct wave length of sun light through to produce Vitamin D in the skin. To live On Land animals had to manage calcium (Ca++) as in the ocean calcium is in solution surrounding sea dwelling organisms. On land, calcium is sourced from foods and calcium management is critical. Vitamin D has proven to be much more than a simple "calcium hormone".

Biochemistry of vitamins and longevity for centenarians The sun turns 7-Dehydro-Cholesterol into Vitamin D3, then the liver converts that to 25(OH)D3 which crosses the cell membrane, and as it turns out all cells use this in thousands of enzyme actions directed by genes (i.e. mRNA transcription!). (19,19a,19b) Vitamin D and it's benefits are difficult to disentangle from those of healthy Sun Exposure, and the other key elements like K2, A, Mg etc. all are inextricably linked and linked to diseases. (20)

This vitamin is known to turn on and off (Gene Expression) over 2000 genes (est. 10% of our genes), and is currently a major area of study and interest. This vitamin requires you to be proactive, study, read, and become a PhD in your own health. Before taking vitamin D you should test your vitamin D blood levels. Test quarterly, but minimum twice a year, and aim for 50 ng/ml. (40-60 ng/ml range) Lifestyle is key, as sun exposure, diet, where on the planet you are, your skin color, and time of year contribute to your health and longevity. For Nudists your probably good, but for Hermits - Test. (TGFG & YT, )

According to Dr. Michael Holick who has been researching Vitamin D for 40 years and pointing out the errors of the AMA and FDA, is one of the leading authorities on Vitamin D. The D-Lightful Vitamin D for Good Health | Dr. Holick, March/2013 explains some of the hundreds of metabolic pathways and causes of longevity diseases. (21,21a)

- This was known almost 60 years ago. Research showed that Vitamin D minimizes the Flu and other respiratory infections. (Irony 1) (Note 3) (22,22a)

Biochemistry of vitamins and longevity for centenarians
Vitamin D status has a linear association with seasonal infections and lung function, 1958. (22,22a)

Prevalence of respiratory infections with 95 % prediction intervals in the 25-hydroxyvitamin D categories of < 25 nmol/l ( ), 25-49 nmol/l ( ), 50-74 nmol/l ( ), 75-99 nmol/l ( ) and >100 nmol/l ( ) as predicted from a logistic regression model adjusted for factors of lifestyle, socio-economic position and adiposity, and season in the 1958 British birth cohort.
Divide by 2.5 = ng/ml, i.e. 10 ng/ml, 10-20 ng/ml, 20-30 ng/ml, 30-40 ng/ml, > 40 ng/ml.
Recommended testing range is 40-60 ng/ml for optimal vitamin D levels. (25) (Note 2)

Vitamin D is so important that your body has evolved to make all the vitamin D it needs. Your skin has evolved as the body's manufacturing source of vitamin D and there are at least 5 other beneficial molecules produced in this process. Vitamin D with Ca++, has been shown to improve mortality. The Vitamin D Council, (How do I get the Vitamin D my body needs?) has guidelines for sun exposure in order to get this vital vitamin and keep the body healthy.

Dr. Patrick has a quick video on vitamin D, The "Vitamin D Sweet Spot" and Its Relationship To Aging | Dr. Rhonda Patrick, August/2013 , (25) and a recent detailed talk on Vitamin D ... Biochemistry of vitamins and longevity for centenarians Diet-Gene Interactions, Epigenetics, the Vitamin D-Serotonin Link and DNA Damage | Dr. Rhonda Patrick, February/2016 . (26)

Ivor Cummins (Engineer) gives an extensive analysis from an engineering studies point of view, and has accumulated references and data in graphical presentations ... D is for Debacle - The Crucial Story of Vitamin D and Human Health | Ivor Cummins BE(Chem), CE MIEI, December/2014 . (27,27b) and Ivor explains cholesterol with a clear discussion ... Wanna know how to collapse your heart disease risk? Ok then. | Ivor Cummins BE(Chem), July.2016 .

    Recent data on Insulin Resistance:
    Dr. Thomas Dayspring aka "Dr. Lipid" and Dr. Kraft - Hyperinsulinemia - Diabetes Epidemic

  1. In reality, the majority of Heart Attacks are due to Insulin Resistance.
  2. LDL is a near-worthless predicator for cardiovascular issues. Low HDL is not good and a better indicator.
  3. Root causes: Sub-Opt Vit D, - Sub-Opt K2, C, Mg, - Excess Fructose and Carbohydrates.- Sub-Opt Omega 3 and Excess Omega 6, Smoking and Pollutants. (27a)
  4. This Inflammation Milieu = Heart Disease Biochemistry of vitamins and longevity for centenarians

    Image and Data: The Fat Emperor - Ivor Cummins (27b)

  5. Insulin Resistance biometrics blows away all of the other biometrics (e.g. BP, 'Cholesterol' metrics, etc. etc.) in terms of direct connection to the disease and death. Ref: Book - by Dr. Joseph R. Kraft - Diabetes Epidemic & You.

- Vitamin D and Omega-3 fatty acids are shown to Extend Telomere Length. These essential nutrients reduce DNA Damage and Inflammation as they work as co-factors in DNA repair genes. Melatonin is part of the sleep cycle and controls over 500 genes in the Sleep Repair Cycle. The Sleep Cycle - Circadian Rhythm is the time duing which your body repairs itself. Exercise also functions as a telomere repair instigator.

To get the vitamin D your body needs for all its cells and tissues, four conditions must be met:

  1. You expose large portions of your body, not just your hands and face. Go Topless ...
  2. You’re outside when UVB rays are at their peak, the only type of wavelengths that produce vitamin D.
  3. You avoid the use of sunscreen during UVB exposure as it can prevent your skin from producing vitamin D.
  4. You’re in a latitude that has adequate UVB rays.

Many people believe taking a walk during a midday break fulfills their vitamin D needs, but you now know that is usually not true. And of these four conditions, the last one may be the biggest deal breaker of all…

 

Vitamin E | A Fat Soluble Vitamin

Vitamin E - Nature's form is Gamma-tocopherol

If using tests (CRP, IL-6, WBC) and tracking nutrients with known effects on inflammation, we know that Omega-3 fatty acids DHA and EPA, Gamma-tocopherol, Flavonoids, Coumarins, Anthocyanins all reduce inflammation. (28) Things that must be minimized are Omega-6 fatty acids and these are pro-inflammatory (linoleic and arachidonic acids, LA, AA). Omega-6 fatty acids are essential but in 1tsp/day levels. Ref: ... this site, Fats - and the Centenarian Diet.

Biochemistry of vitamins and longevity for centenarians

γ tocopherol is the major form of vitamin E in many plant seeds and in the US diet, but has drawn little attention compared with alpha-tocopherol, the predominant form of vitamin E in tissues and the primary form in supplements. However, recent studies indicate that gamma-tocopherol may be important to human health and that it possesses unique features that distinguish it from alpha-tocopherol. Gamma-Tocopherol appears to be a more effective trap for lipophilic electrophiles than is alpha-tocopherol. (28a)

Dr. Ames' Triage Theory is at work here as typically, anthocyanins and other flavonoid components, or anthocyanins and other nonflavonoid phytochemicals, are interacting together in order to provide full potency. Interactions between phytochemicals within a plant are a key evolutionary strategy for the host plant. There are over 4000 flavonoids described, with multiple substitution patterns and often large complex structures in the mixtures. (28b,c,d,e,f) (Note 4)

The anthocyanins and related flavonoids are secondary products typically produced by plants as defensive, protective, or attractive agents, and it makes good evolutionary sense for the plant to use a variety of strategies and multiple fronts of attack to accomplish these functions, rather than single compounds to which a pathogen or predator could become resistant. This same multiplicity in bioactive phytochemical synthesis is also a bonus for animals and humans who ingest the plant material donors, and benefit from the interaction of the flavonoids with therapeutic targets. Interestingly ... this same "Cocktail" approached is used in "Cancer and HIV" treatments. ... did Nature invent it first?

Note: supplemented forms of Vitamin E, can have alpha as leading tocopherol, which can then down-regulate the gamma form from food sources. ... it is not nice to fool with Mother Nature.

 

Vitamin K's - Menaquinones | Fat Soluble Vitamins

Blood and Calcium Control and K Vitamins

... it is estimated that 65% of the US has inadequate Vitamin K. Vitamin K1 and K2 are active in blood clotting and prevention of calcification of arteries. Accumulating evidence suggests that atherosclerotic calcification shares features with bone calcification. Vascular calcification, or hardening of the arteries, is common and clinically significant in atherosclerosis. Ref: Vitamin D and Bone Health, - and - Vitamin D and Healthy Skin - and - Vitamin K and Bone health.

Example: Blood Clotting is the primary function of K1. Your body will sacrifice your health to favor Calcium and Blood Clotting over other nutritional pathways. This was shown as part of the Dr. Ames Triage Theory.

are the naturally occurring form of vitamin K identified in bacteria. Lipid extracts were made from three bacteria originally isolated from the human neonatal gut and identified as Enterobacter agglomerans, Serratia marcescens and Enterococcus faecium. If your Gut Microbiome is healthy, evidence suggests that bacterially synthesized menaquinones, particularly in the ileum can and do play a significant role in contributing to vitamin K requirements in humans to prevent clinically significant coagulopathy, especially during periods of episodic dietary lack of the vitamin. (24,24a)

Vitamin K1, is also called phylloquinone or menaquinone 4. It is typically found in dark green leafy vegetables and used in photosynthesis. Vitamin K2 includes a range of vitamin K forms collectively referred to as menaquinones. Most menaquinones are synthesized by human Intestinal Microbiota, and found in fermented foods and in animal products.

Vitamin K1 or phylloquinone is synthesized by plants and is the predominant form in the diet. Vitamin K2 includes a range of vitamin K forms collectively referred to as menaquinones. Most menaquinones are synthesized by human intestinal microbiota and found in fermented foods and in animal products.

Dr. Kate Rheaume-Bleue on Vitamin K's and Heart Disease and Cancers ...

Dr. Mercola Interviews Dr. Kate Rheaume-Bleue - Jan/2013

Dr. Kate Rheaume-Bleue. Boy. Vitamin K2 and the Calcium Paradox -

The popular form of vitamin K2 has the chemical name menaquinone 7 and is synthesized by intestinal bacteria, and absorbed from the distal small bowel. Antibiotics have been shown to reduce vitamin K2 from this source. Broad spectrum antibiotics kill everything, if taking antibiotics and you are feeding your Gut Microbiome - Sugars and Refined Carbohydrates, you are really screwed. Refined carbohydrates cause the wrong type of bacteria to grow, hence, Malnutrition - Chronic Inflammation.

Brie and Guda Cheeses are also the best sources of K's, and provide about 75 ug per ounce of cheese. In addition, all grass fed sources of eggs and meats are good. Fermented vegetables are the best as 1 ounce of some fermented vegetable can provide up to 1 Trillion Bacteria and 500 ug of K's. Not Yogurts, the bacteria in yogurts do not provide K's.

- about how our ancestors walked around the neighborhood and ate everything ... to include rotting foods, i.e. fermentation. We learned ... from other animals and also our own experimentation. We are the "Smart Opportunist" | contributor September/2016. Fermented foods typically have the highest concentration of vitamin K2 found in the human diet and can provide several milligrams of vitamin K2 on a daily basis. This level far exceeds the amount found in dark green vegetables.

Vitamin K1 and K2 work with Vitamin D (preferable from the Sun - UVB specifically) for blood clotting and calcium deposition and removal control. Other minerals are also co-factors, and sulfur - Cruciferous Veggies, i.e. broccoli, etc.

A good example of Dr. Ames' Triage Theory is demonstrated when calcium is released from the bones into the blood stream as a short-term survival response to reduce the metabolic over-acidity caused by high protein intake. This "short term" emergency measure taken by the body, often results in the long-term consequences of osteoporosis. Practitioners who use nutritional approaches have long recognized this consequence of a high protein diet. (23,23a23b)

This type of cellular metabolism, has also been shown for Vitamin K-dependent (VKD) proteins and blood clotting (coagulation). When there is a deficiency in vitamin K1, the body reserves the K1 for Blood Clotting a critical protein function. The other protein pathways that uses K1, Calcification show less activity and hence aging and slow deterioration and mutations ... i.e. Triage. No change in clotting, but the rest of the body suffers a loss of function, such as DNA repair which is impaired. (23,23d) Ref: ... the Centenarian Diet and Vitamins.

Malnutrition = Bad Blood, and with missing macronutrients (fats and proteins) circulating coupled with a mineral imbalance, and again your screwed. Dr. Stephanie Seneff points out that in 1960 the scientific community knew that Sulfur was another critical mineral and functioned with cholesterol to protect our cell walls and blood chemistry. Cholesterol-Sulfate, Vitamin D, Vitamin Ks work together to control

Vitamin D and bone health for longevity and becoming a centenarian - minerals are from your diet, calcium C++, magnesium Mg++, manganese Mn++. Calcium is stored in your bones and the body can use it for other metabolic functions. Magnesium, and Manganese need to be gotten daily from your diet.

 

Multi - Vitamins and Minerals

The evidence is still murky that they are effective, in fact there is some evidence of deleterious effects of some of the trace metals. This is a clear case where Do you take Supplements? and your answer might be ... No, I eat food. A Multi- requires you to be proactive, study, read, and become a PhD in your own health. (TGFG & YT, )

Biochemistry of vitamins and longevity for centenarians The Chinese are the largest consumer of supplements now, especially since they now have the largest middle class of any country. A 26 week study in 2010 with multivitamin supplements showed that the group on supplements lost more weight, about 3 kg more, and improved their health markers. Among other things, their basal metabolic rate (the rate at which the body burns calories when at rest) increased. (29) And from the British Journal of Nutrition - Multivitamin and dietary supplements, body weight and appetite study, (29a), male consumers of vitamin and/or dietary supplements had a lower body weight, fat mass, BMI, and a tendency for greater resting energy expenditure.

Biochemistry of vitamins and longevity for centenarians We need twice the amount of K+ as Na+, and RDA is 4500mg and 2300mg respectively. However, with a LCHF lifestyle we have to rethink sodium and potassium. The kidneys will excrete sodium and potassium and imbalances cause risk to the heart and muscles. In a large study of 102,000 people over 3.7 years, indicated the lowest risk of death and cardiovascular events was seen among participants with an estimated sodium excretion between 3 g per day and 6 g per day (7.5 to 15.0 g of salt per day). Both higher and lower levels of estimated sodium excretion were associated with increased risk.

The optimal and lowest mortality rate was about 5,000 mg sodium per day and ketosis accelerates sodium excretion. Molar mass salt 58.44 g/mol, by weight 22.99 Na+, 35.45 Cl-, ratio 1:1.5 this implies that a gram of salt is 393mg of Na+. (29b) An excretion of K+ > 2 g per day is optimal. The issue we have today is getting enough potassium K+ in our diet. (29c)

Longevity and the triage theory of nutrients However, studies from both the U.S. (29,d,e,f,g,h) and the U.K. (29i)suggest a majority of people fail to get certain key vitamins and minerals from food alone. Topping this list are vitamins D, E, A, C, magnesium (Mg++) and calcium (Ca++). Omega 3s, vitamin K2 (fermentation), potasium (K+) are all important and they directly effect bone health and cardiovascular health. Also, The Heart's Electrical System and Abnormal Rhythms | contributor, june/2016.

Magnesium (Mg++) deficiency is hard to detect, as only 1% of the magnesium in your body is found in your blood stream. Instead, most of your magnesium will be found stored in your bones and organs. It is quite possible to be unaware of a deficiency, which is why it has been dubbed the “invisible deficiency.” Some researchers estimate that up to 80 percent of American do not get enough magnesium from their diet to replace the magnesium lost. (29j,k) Think Green as Mg++ makes vegetables green

Example: calcium supplements have been linked with CVD (cardiovascular disease), but the real culpret is an imbalance. Calcium Must Be Balanced With Vitamin D, Magnesium and K2. Calcium is one of several nutrients required for strong, healthy bones. However, it's important to not overdo it on calcium supplements, as it needs to be balanced with vitamins D, K2 and magnesium. Dr. Rheamue-Bleue discusses this with Dr. Mercola and also reference Cheese - What is Best for Health | contributor - june/2016

ER Ca2+ handling integrity is critical for synaptic function. Although the endoplasmic reticulum (ER) extends throughout axons, axonal ER dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is poorly understood. New research shows that Ca2+ is actively involved in plasma membrane (PM) function and the control of neurotransmitter release. (29l) Dr. Ames' Triage Theory - (Key) shows other examples of how the body balances Ca2+.

 

Supplements - The Good, the Bad, the Ugly

Dr. Mercola sells supplement, but is more interested in eating right, this is called Functional Medicine. He explains ... Change the Game by Taking Control of Your Health | August/2016 . Vitamins are classified as either fat soluble (vitamins A, D, E and K) or water soluble (vitamins B and C). This difference between the two groups is very important. It determines how each vitamin acts within the body. ... Dr. Rhonda Patrick | Rebuttal to Anti-Vitamin Editorial: "Enough is Enough" february/14 (40)

Vitamins are essential and can be overdosed. Without the surrounding proteins, fats, and complex carbohydrates that comes with eating whole foods, it is easy to overdose on vitamins and the side effects can be disastrous. There is a huge amount of literature on this, take heed. As usual, Dr. Ames (at 85, and fighting the good fight) can explain the pathways of nutrition, Vitamin and Mineral Inadequacy Accelerates Aging-associated Disease | Dr. Bruce Ames | march/14. And Dr. Jeffery Tice, UCTV, has a discussion The ABC and Ds of Vitamin Supplements and Health | Dr. Jeffery Tice | march/12.

Biochemistry of vitamins and longevity for centenarians Supplement labels: unfortunately, there is no requirement for supplement labels to warn of toxicities. ConsumerLab.com has shown in their B Vitamin Supplements Review, (41) many vitamins and energy drinks exceed the established Upper Tolerable Intake Levels (which vary by age) for B vitamins. If you have an established deficiency, high doses may be necessary; otherwise, remember that "more" does not necessarily mean "better."

The Triage Theory posits that our body selects short term survival over longevity pathways when there is a shortage of micronutrients ... Dr. Patrick on Micronutrients for the Prevention of Age-Related Diseases and Brain Dysfunction | june/2016. A prominent theory of aging holds that decaying of mitochondria, Mitochondrial Dysfunction, is a key driver of aging. While it's not clear why our mitochondria fade as we age, evidence suggests that it leads to everything from heart failure to neurodegeneration. DNA repair is the issue. DNA - Repair, PubMed, and DNA Repair - Video, NutritionalFacts.org.

But the Good/Bad News is Pharmaceutical Drugs are 62,000 Times More Likely to Kill You than Supplements according to the Alliance for Natural Health International (ANH-Intl). (11a,11b) i.e. "Natural Health products Ultra-safe - Drugs as Dangerous as War".

 

Quick Facts ...

    Fat-Soluble Vitamins: A, D, E, and K

  1. Small amounts of vitamin A, vitamin D, vitamin E and vitamin K are needed to maintain good health.
  2. Fat-soluble vitamins will not be lost when the foods that contain them are cooked.
  3. The body does not need these vitamins every day and stores them in the liver and adipose (fat) tissue when not used.
  4. Most people do not need vitamin supplements with proper diet.
  5. Megadoses of vitamins A, D, E or K can be toxic and lead to health problems.
  6. Requirements for vitamins may be expressed in different mathematical units. Close attention should be paid to ensure that similar units are being compared.
  7. Source: Colorado State University- Fat-Soluble Vitamins: A, D, E, and K, by L. Bellows and R. Moore (11/12).

The fat-soluble vitamins, A, D, E, and K, are stored in the body for long periods of time and generally pose a greater risk for toxicity when consumed in excess than water-soluble vitamins. Eating a normal, well-balanced diet will not lead to toxicity in otherwise healthy individuals. However, taking vitamin supplements that contain megadoses of vitamins A, D, E and K may lead to toxicity. The body only needs small amounts of any vitamin. More ...

 

Ok - Now What?

Anti Aging Nutrition for any Age

are the primary effort of every living animal on this planet. Even plants must seek nutrition and fertile soils with a living microbiome - soil health, to thrive. Humans are no different, as we sometimes forget why we eat. We carry our own microbiome - guts and are seeking Energy for survival, and Nutrition for growth and disease control. Supplying the body with proper nutrition is our reason for eating. ... D. S. McGerk | conbtributor, april/16. What's Cooking?: The Meat and Potatoes of Human Evolution ... Dr. Jeanne Sept | july/13. (42) Catching Fire: How Cooking Made Us Human ... Dr. Richard Wrangham | february/13. (43) The rise of Omega 6 fats, and where did the Omega 3's go from our food sources ... D. S. McGerk | contributor, may/16

 


Irony Notes:

  1. Ironically, all that was/is needed to control/mitigate respiratory diseases was the measure Vitamin D levels. Being aware that vitamin D levels are a function of sunlight, sking color, and location on this planet.

Notes:

  1. Sun exposure is the primary source of vitamin D for most people. (30,35,36) The vitamin D made by your body last 3 times longer than supplement vitamin D, the reason is obvious in that there is much more going on with this manufacturing process. (31,32,32a,33,34)
  2. In vitamin D deficiency, calcium absorption cannot be increased enough to satisfy the body's calcium needs. (30) Before taking vitamin D you should test your vitamin D blood levels. Test quarterly, but minimum twice a year, and aim for 50 ng/ml. (40-60 ng/ml range) Lifestyle is key, as sun exposure, diet, where on the planet you are, your skin color, and time of year contribute to your health and longevity.
  3. This is the kind of nutritional science that conveniently gets overlooked by the AMA, NIH, FDA, and their reliance on Big-Pharma to do their research for them.
  4. Hypothesis: "... the body's rationing response to shortages of micronutrients. Scarce micronutrient are reallocated to nutritional pathways essential for short-term survival. Pathways needed for long term health, (including those that protect DNA), lose out leading to the diseases of aging.

 


Aside cell 3
Track Your Nutrition &amp; Health Data with cronometer.com

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  3. TGFG & YT Thank God For Google and youTube Research Tools:
  4. RDAs The recommended dietary allowance (RDA) was developed during World War II by Lydia J. Roberts, Hazel Stiebeling, and Helen S. Mitchell, all part of a committee established by the United States National Academy of Sciences in order to investigate issues of nutrition that might "affect national defense".
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is a positive online community for seniors who are interested in longevity and becoming centenarians. Living to 100 years of age becomes a goal, and sharing and exploring this goal is an issue that matters to those in the golden years. A platform for the energetic, creative, and productive, to share life experiences by contributing your experiences on this site. Founded to explore quality living, healthy and anti aging, longevity and Becoming Centenarians.