Vitamins - and the Centenarian Diet
Vitamins are co-factors that work hand in hand with the bodies enzymes. They work synergistically with other vitamins. These important compounds are critical to DNA repair, as the repair enzymes in the cell are always moving along the DNA and repairing incorrect chemical sequences and other compounds. The current theory is that any failure here is "Aging".
Aging is a "Process", whereas Longevity is a "Measurement". For example, we know that a Vitamin D Deficiency will cause premature aging. (1) As usual, Dr. Ames - "Triage Theory"" (at 85, and fighting the good fight) can explain the pathways of nutrition, Vitamin and Mineral Inadequacy Accelerates Aging-associated Disease | Dr. Bruce Ames | march/14. Dr. Rhonda Patrick has a current lecture on Micronutrients for the Prevention of Age-Related Diseases and Brain Dysfunction | Dr. Rhonda Patrick | June/2016 (2,2a,2b,2c)
Key Knowledge: You are turning off your immune system with a poor diet. The body favors short-term survival over long-term health. This trade-off accelerates aging-associated diseases, such as cancer, cardiovascular disease, immune dysfunction, and cognitive decline.
High carbohydrate diets, that are also high in omega-6 fats, shut down and confuse the body’s own antioxidant defense genes which are far more powerful than any supplement you can take. Unrecognizble free radicals are created.
Enzymes within the body pair up with over 30 vitamin compounds and dozens of minerals to perform many tasks within the cells and microbiome of the human organism and our gut microbiome. Our body is a constant temperature chemical soup and "Without Enzymes and their Interactions" metabolism would stop, and no chemical processes would ocurr. This "Co-factoring" is occurring 100 million times per second, and every second, and is never ending ... we replace approximately 300 Billion cells per day.
Minerals are involved in tens of thousands of individual enzyme reactions within the body, (ex. zinc is known to be involved with over 2000 different enzyme reactions). Every DNA repair enzyme has magnesium Mg in it - Ca, Fe, S, Se, K, Na, Cl, etc., these minerals also act as co-factors for enzymes along with vitamin compounds both in the water and fats in the body. Many of the minerals are toxic if you get too many, just as too few will stop enzyme actions. Ref: ... this site, "Eating Habits - Risky." Also, Dr. Bruce Ames explains this in his research.
Nature trades short term survival for long term health. This is the view of the Centenarian Diet.
Fermented foods have been on our planet much longer than humans, and is a natural process. Eating fermented foods, is also part of the Centenarian Diet.
Example: Vitamin K1 from greens, K2 from fermented food, in Japan
Natto is considered a health food,
critical in blood clotting and calcium transport, proper transport is important in calcification in bones and in our circulatory-blood system.
Dr. Stephanie Seneff proposes that atherosclerosis and neural damage occurs when our "Dietary Cholesterol" is deficient, and we have a sun exposure and vitamin D deficiency (est. 50% pop), coupled with a sulfur (S) deficiency leads to atherosclerosis and myelin sheath and collagen damage. (5) Remember we have been told not the eat ... egg yolk - Eggs the prefect Breakfast.
New evidence gives insight into how Vitamin D regulates the SRE lipogenic genes and lipid metabolism. Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control lipid homeostasis. 25-hydroxyvitamin D (25OHD) has been identified as an inhibitor of SREBP activation. (5a)
Every day we are learning more ...
Macular Degeneration is a shortage of 2 carotenoids out of a possible 600 ... this is an argument, that these carotenoids
(polyphenols) should be classified as
Longevity Vitamins (6,7,8).
Dr. Bruce Ames - Hypothesis: "... the body's rationing response to shortages of micronutrients. Scarce micronutrient are reallocated to nutritional pathways essential for short-term survival. Pathways needed for long term health, (including those that protect DNA), lose out leading to the diseases of aging. (2,2a,2b,3,3a)
This hypothesis opens up the aging process for questions, and we can ask what "Longevity Vitamins" are yet to be discovered. Vitamins by definition are those micronutrients critical for life, without which we die. This theory postulated that there are micronutrients critical for aging and longevity, without which we age poorly. Polyphenols can easily be a key element in this new paradigm of
Dr. Bruce Ames: | Triage Theory of Micronutrients
Dr. Bruce Ames, on Longevity Vitamins, has several great youTube videos on Triage Theory, Longevity Vitamins & Micronutrients, (10,11,11a) where he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution. When cells run out of a vitamin or mineral, that scarce micronutrient is allotted to proteins (in the body) essential for short-term survival. Proteins needed for long-term health, including those that protect DNA, lose out and become disabled and lead to diseases of aging... Vitamin & Mineral Inadequacy Accelerates Aging-associated Disease | Dr. Ames, may/2015 , (12,13)
- Most of the world's population has inadequate intake of one or more micronutrients.
- Triage theory posits as a result of recurrent shortages of micronutrients during evolution, natural selection developed a metabolic rebalancing response to shortage.
- The rebalancing favors micronutrient-dependent protein needed for short term survival while those only required for long-term health are starved.
- This impairment results in insidious damage (e.g. increased DNA damage) that, over time, leads to the acceleration of age-associated diseases (e.g. increased cancer).
A good example of Dr. Ames' Triage Theory is demonstrated when calcium is released from the bones into the blood stream as a short-term survival response to reduce the metabolicover-aciditycaused by high protein intake. This "short term" emergency measure taken by the body, often results in the long-term consequences of osteoporosis. Practitioners who use nutritional approaches have long recognized this consequence of a high protein diet. (14) This type of cellular metabolism, has also been shown for Vitamin K-dependent (VKD) proteins and blood clotting (coagulation). (15) Ref: ... the Centenarian Diet and Vitamins and Vitamin K.
In addition Dr. Ames discuss how RDAs (16) are chosen and what he calls "longevity vitamins". Longevity vitamins he calls a class of nutrients that exist mostly to prevent degenerative diseases of aging in addition to the essential vitamins and minerals we are familiar with. These are just now being identified.
The last 15 year have changed the landscape in our understanding of longevity pathways and regulation of life-span, Just 1 Example:
[Shino Nemoto, et al. Science 17 Dec 2004: Nutrient Availability Regulates SIRT1 ...]Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that in mammalian cells, acute nutrient withdrawal simultaneously augments expression of the SIRT1 deacetylase and activates the Forkhead transcription factor Foxo3a. ... nutrient-sensitive physical interaction was observed ... in mammalian cells, p53, Foxo3a, and SIRT1, three proteins separately implicated in aging, constitute a nutrient-sensing pathway.(17)
The Company of Biologists - Development: When stem cells grow old: phenotypes and mechanisms of stem cell aging, Michael B. Schultz, David A. Sinclair (17a)
Another Example, and very familiar, of a Nutrient Sensing and Metabolism pathway, is the most robust longevity-extending intervention across species -
Calorie Restriction (CR) -
without malnutrition. The benefits of CR may be exerted through altered
Stem Cell phenotypes. [Schultz, Sinclair, 2016.]
"Caloric restriction causes reduced levels of insulin, IGF and amino acids, and increased levels of NAD+ and AMP. These changes are sensed by the insulin-IGF signaling (IIS) pathway, target of rapamycin (TOR), sirtuins and AMP kinase (AMPK), resulting in enhanced DNA repair, stability of the epigenome, stress resistance, oxidative metabolism and ultimately, longevity. All of these signals, sensors and responses regulate stem cell behavior." (17a)
Stem Cells are among the longest-living cells within an organism, stem cell aging is highly relevant as a driver of organismal aging, health and longevity. Ref: Time Restricted Feeding (TRF) and the
Circadian Rhythm, our Metabolic Clock | contributor August/2016, as
Sleep/Fasting cycle provides functional fasting and
calorie restriction (CR).
Longevity Vitamins are a new area where the list of micronutrients that are need for longevity will be very long. Solution Part 1: high density micronutrient smoothies,
... Dr. Rhonda Patrick | january/15 (18)
... D. S. McGerk | contributor, april/16 and this site
The Antioxidant Protein Smoothie,
Epigenetics is critical to the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism
and the biological consequences of this dynamic relationship.
Dr. Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance | april/15 (19,19a)
Our diet also influences which of these genes are turned on or off! Emerging evidence in the field of
Epigenetics has demonstrated that not only can we change the expression of our own genes within our own lifetime;
sometimes these changes are heritable and affect our children and grandchildren.
Dr. Dean Odell | Talk Show Host Medical Doctor
Dr. Dean Edell (20) was a long time radio talk show host in the San Francisco Bay Area.
A caller once called in and asked Dr. Edell ...
Do you take Supplements? and his answer was a clarification to his listeners in its simplicity ...
No, I eat food.
From the back cover of "Eat, Drink & Be Merry, Dean Edell, M.D."
"... As one of the first media doctors, Dr. Edell knows better than anyone the dangers of distorted medical reporting. With colorful detail, he shows how medical consumers are made neurotic at a time when people are healthier than ever before. Dr. Edell sorts through the morass of research, distinguishing documentable fact from panic-inducing fiction. With trademark humor, grace, and style, he shares with us the essential reassuring facts about our health: you can be fatter than you think; too much exercise might kill you; and yes, sex will add years to your life!"
Supplements - The Good, the Bad, the Ugly
Dr. Mercola sells supplement, but is more interested in eating right, this is called
Functional Medicine. He explains ...
Change the Game by Taking Control of Your Health | August/2016 . Vitamins are classified as either fat soluble (vitamins A, D, E and K) or water soluble (vitamins B and C).
This difference between the two groups is very important. It determines how each vitamin acts within the body.
... Dr. Rhonda Patrick | Rebuttal to Anti-Vitamin Editorial: "Enough is Enough" february/14 (21)
The Chinese are the largest consumer of supplements now, especially since they now have the largest middle class of any country. A 26 week study in 2010 with multivitamin supplements showed that the group on supplements lost more weight, about 3 kg more, and improved their health markers. Among other things, their basal metabolic rate (the rate at which the body burns calories when at rest) increased. (22) And from the British Journal of Nutrition - Multivitamin and dietary supplements, body weight and appetite study, (23), male consumers of vitamin and/or dietary supplements had a lower body weight, fat mass, BMI, and a tendency for greater resting energy expenditure.
Vitamins are essential and can be overdosed. Without the surrounding proteins, fats, and complex carbohydrates that comes with eating whole foods, it is easy to overdose on vitamins and the side effects can be disastrous. There is a huge amount of literature on this, take heed. As usual, Dr. Ames (at 85, and fighting the good fight) can explain the pathways of nutrition, Vitamin and Mineral Inadequacy Accelerates Aging-associated Disease | Dr. Bruce Ames | march/14. And Dr. Jeffery Tice, UCTV, has a discussion (UCTV, University of California TV) The ABC and Ds of Vitamin Supplements and Health | Dr. Jeffery Tice | march/12.
Supplement labels: unfortunately, there is no requirement for supplement labels to warn of toxicities. ConsumerLab.com has shown in their B Vitamin Supplements Review, (25) many vitamins and energy drinks exceed the established Upper Tolerable Intake Levels (which vary by age) for B vitamins. If you have an established deficiency, high doses may be necessary; otherwise, remember that "more" does not necessarily mean "better."
The Triage Theory proposes that our body selects short term survival over longevity pathways when there is a shortage of micronutrients
Dr. Patrick on Micronutrients for the Prevention of Age-Related Diseases and Brain Dysfunction | june/2016 ,
A prominent theory of aging holds that decaying of mitochondria,
Mitochondrial Dysfunction, is a key driver of aging.
While it's not clear why our mitochondria fade as we age, evidence suggests that it leads to everything from heart failure to neurodegeneration. DNA repair is the issue.
DNA - Repair, PubMed, and DNA Repair - Video, NutritionalFacts.org.
Ok - Now What?
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids and lipids, and surrogate metabolites, are then integrated and coordinated at the organismal level via hormonal signals. (30)
When discussing the cause, set of causes, or causations of aging, one must be careful not to describe aging as a genetically programmed phenomenon on par with embryonic development or adult homeostasis. Many of the mechanisms that drive stem cell aging exist because they ostensibly confer health and survival benefits during development or youth but are deleterious later in life. (17,17a)
Stem Cells exist in all our organs - Skin to Bone - and are an intregral part of the Repair and Immune Response
of organisms. This is all new Science.
Simple solution, avoid carbohydrates as they offer no known nutritional benefits. Carbohydrates are however packaged in food source organisms that do provide Longevity Vitamins, Our foods provide Phytonutrients, macronutrients, micronutrients (for critical DNA repair) (R1), Polyphenols, Phytosterols, Flavonoids, Lignans, Antioxidants, and Carotenoids, that do allow life to continue. Ref: 100 richest dietary sources of polyphenols. (Resource 1,2,3)
Certainly avoid processed carbohydrates, fats and oils, any packaged and foods. A direct result of too many carbohydrates is Insulin Resistance functional manifested as Carbohydrate Intolerance. Dr. Volek discusses his current views on the benefits of a LCHF plan - Health-Promoting Effects of a Low-Carbohydrate Lifestyle | july/2016 and this site follows this type of plan with the addition of Dr. Ames' "Triage Theory" ... the Centenarian Diet.
What path are You On?